Patzakis M J, Ivler D
South Med J. 1977 Oct;70 Suppl 1:46-8. doi: 10.1097/00007611-197710001-00013.
A prospective study involving 581 open fracture wounds was conducted to evaluate the antibiotic and bacteriologic considerations in the treatment of open fractures. Multiple cultures were taken of each wound, and each wound had formal surgical irrigation and debridement. An organism was present in at least one of the multiple cultures in 62.1% of the cases. Open fractures should be considered as contaminated wounds, and antibiotics are given for treatment rather than prophylaxis.
一项涉及581例开放性骨折伤口的前瞻性研究，旨在评估开放性骨折治疗中的抗生素及细菌学相关因素。对每个伤口进行多次培养，且每个伤口都进行了正规的手术冲洗和清创。62.1%的病例在多次培养中至少有一次培养出微生物。开放性骨折应被视为污染伤口，给予抗生素是用于治疗而非预防。
