Department of Nutrition, School of Public Health, University of Sao Paulo, SP, Brazil; University of Fortaleza (UNIFOR), Nutrition Course, Fortaleza, Brazil.
Department of Nutrition, School of Public Health, University of Sao Paulo, SP, Brazil.
Nutrition. 2021 Mar;83:111082. doi: 10.1016/j.nut.2020.111082. Epub 2020 Nov 20.
Advances in metabolomic tools have allowed us to gain a more comprehensive understanding of metabolic syndrome (MetS). The aim of this study was to evaluate the association between plasma metabolomic profiles and MetS.
For this study, adults without diabetes, chronic kidney disease, stroke, heart disease, or cancer and with full metabolomics, biochemical, and dietetic data available, representing a subsample of the Health Survey of Sao Paulo study (ISA-Capital; N = 130), were included. The joint interim statement consensus criteria were used for diagnosing MetS. Absolute quantification (µmol/L) of blood metabolites was achieved by targeted quantitative profiling of annotated metabolites by electrospray ionization tandem mass spectrometry in plasma samples. Mean differences in the compounds for MetS were evaluated by linear regression adjusted for confounding factors.
Serine was inversely associated with MetS (β = -15.04; P = 0.014). In glycerophospholipids with acyl-alkyl bonds, there was an inverse association with MetS, including phosphatidylcholine (PC) ae C42:5 (β = -0.15; P = 0.040), PC ae C44:5 (β = -0.15; P = 0.046), PC ae C40:4 (β = -0.21; P = 0.014) and PC ae C44:4 (β = -0.04; P = 0.032).
Plasma metabolomic profiles were associated with MetS, especially the amino acid serine and some acyl-alkyl PCs.
代谢组学工具的进步使我们能够更全面地了解代谢综合征（MetS）。本研究旨在评估血浆代谢组学谱与 MetS 的关系。
本研究纳入了无糖尿病、慢性肾脏病、卒中和心脏病或癌症且具有完整代谢组学、生化和饮食数据的成年人，这些数据代表了圣保罗健康调查（ISA-Capital；N=130）的一个亚样本。采用联合临时声明共识标准诊断 MetS。通过电喷雾串联质谱对血浆样本中注释代谢物进行靶向定量分析，实现血液代谢物的绝对定量（µmol/L）。通过线性回归调整混杂因素评估代谢物与 MetS 的差异。
丝氨酸与 MetS 呈负相关（β=-15.04；P=0.014）。在具有酰基-烷基键的甘油磷脂中，与 MetS 呈负相关，包括磷脂酰胆碱（PC）ae C42:5（β=-0.15；P=0.040）、PC ae C44:5（β=-0.15；P=0.046）、PC ae C40:4（β=-0.21；P=0.014）和 PC ae C44:4（β=-0.04；P=0.032）。
血浆代谢组学谱与 MetS 相关，尤其是氨基酸丝氨酸和一些酰基-烷基 PC。
