Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands.
Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands.
Curr Opin Cell Biol. 2021 Jun;70:51-57. doi: 10.1016/j.ceb.2020.11.006. Epub 2020 Dec 25.
A large proportion of the metazoan genome is spatially segregated at the nuclear periphery through genomic contacts with the nuclear lamina, a thin meshwork of lamin filaments that lines the inner-nuclear membrane. Lamina-associated domains are believed to contribute to the regulation of gene transcription and to provide structural three-dimensional support to the organization of the genome in A and B compartments and topologically associating domains. In this review, we will evaluate recent work addressing the role of lamina-associated domains in three-dimensional genome organization and propose experimental frameworks that may expand our understanding of their interdependence.
大量后生动物基因组通过与核纤层的基因组接触而在核周空间分离，核纤层是一种薄的核纤层丝网格，排列在内核膜的内表面。核纤层相关域被认为有助于基因转录的调控，并为基因组在 A 和 B 区室以及拓扑关联域中的三维组织提供结构三维支持。在这篇综述中，我们将评估最近解决核纤层相关域在三维基因组组织中的作用的工作，并提出可能扩大我们对它们相互依存关系的理解的实验框架。
