少突胶质细胞谱系细胞的表观遗传学景观。
The epigenetic landscape of oligodendrocyte lineage cells.
机构信息
Graduate Program in Biochemistry, The Graduate Center of The City University of New York, New York, New York, USA.
Neuroscience Initiative, Advanced Science Research Center, The Graduate Center of The City University of New York, New York, New York, USA.
出版信息
Ann N Y Acad Sci. 2023 Apr;1522(1):24-41. doi: 10.1111/nyas.14959. Epub 2023 Feb 5.
The epigenetic landscape of oligodendrocyte lineage cells refers to the cell-specific modifications of DNA, chromatin, and RNA that define a unique gene expression pattern of functionally specialized cells. Here, we focus on the epigenetic changes occurring as progenitors differentiate into myelin-forming cells and respond to the local environment. First, modifications of DNA, RNA, nucleosomal histones, key principles of chromatin organization, topologically associating domains, and local remodeling will be reviewed. Then, the relationship between epigenetic modulators and RNA processing will be explored. Finally, the reciprocal relationship between the epigenome as a determinant of the mechanical properties of cell nuclei and the target of mechanotransduction will be discussed. The overall goal is to provide an interpretative key on how epigenetic changes may account for the heterogeneity of the transcriptional profiles identified in this lineage.
少突胶质细胞谱系细胞的表观遗传景观是指 DNA、染色质和 RNA 的细胞特异性修饰，这些修饰定义了功能特化细胞的独特基因表达模式。在这里，我们专注于发生在祖细胞分化为髓鞘形成细胞并对局部环境作出反应时的表观遗传变化。首先，我们将回顾 DNA、RNA、核小体组蛋白、染色质组织的关键原则、拓扑关联域和局部重塑的修饰。然后，将探讨表观遗传调节剂与 RNA 处理之间的关系。最后，将讨论作为核力学性质决定因素和机械转导靶标的表观基因组的相互关系。总体目标是提供一个解释性的关键，说明表观遗传变化如何解释该谱系中鉴定出的转录谱的异质性。
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