Department of Plant and Microbial Biology, North Carolina State University, Raleigh, NC, USA.
Department of Plant and Microbial Biology, North Carolina State University, Raleigh, NC, USA.
Curr Opin Virol. 2021 Apr;47:18-24. doi: 10.1016/j.coviro.2020.12.002. Epub 2020 Dec 25.
Geminiviruses are a family of single-stranded DNA viruses that infect many plant species and cause serious diseases in important crops. The plant protein kinase, SnRK1, has been implicated in host defenses against geminiviruses. Overexpression of SnRK1 makes plants more resistant to geminivirus infection, and knock-down of SnRK1 increases susceptibility to geminivirus infection. GRIK, the SnRK1 activating kinase, is upregulated by geminivirus infection, while the viral C2 protein inhibits the SnRK1 activity. SnRK1 also directly phosphorylates geminivirus proteins to reduce infection. These data suggest that SnRK1 is involved in the co-evolution of plant hosts and geminiviruses.
双生病毒是一类感染多种植物物种并导致重要作物严重疾病的单链 DNA 病毒。植物蛋白激酶 SnRK1 被牵连到宿主对双生病毒的防御中。SnRK1 的过表达使植物对双生病毒感染更具抗性，而 SnRK1 的敲低则增加了对双生病毒感染的敏感性。GRIK，即 SnRK1 激活激酶，受双生病毒感染上调，而病毒 C2 蛋白抑制 SnRK1 活性。SnRK1 还直接磷酸化双生病毒蛋白以减少感染。这些数据表明，SnRK1 参与了植物宿主和双生病毒的共同进化。
