Allen D R, Browse N L, Rutt D L, Butler L, Fletcher C
Department of Surgery, St. Thomas Hospital, London, England.
J Vasc Surg. 1988 Jan;7(1):139-52.
The association between cigarette smoking and the development of atherosclerosis is well established, but the mechanism that makes cigarettes such a potent "risk factor" is not understood. There is normally a constant insudation of plasma macromolecules into the arterial wall. Fibrinogen and lipids are two of the large molecules involved in atherosclerosis. Therefore we studied the effect of cigarette smoke, nicotine, and carbon monoxide on the permeability of the canine arterial wall to 125I-labeled fibrinogen. The results show that inhaled cigarette smoke significantly and rapidly increases the permeability of the arterial wall to fibrinogen and that this effect can be produced with carbon monoxide alone but not with intravenous nicotine.
吸烟与动脉粥样硬化的发展之间的关联已得到充分证实，但香烟成为如此强大的“风险因素”的机制尚不清楚。正常情况下，血浆大分子会持续渗入动脉壁。纤维蛋白原和脂质是参与动脉粥样硬化的两种大分子。因此，我们研究了香烟烟雾、尼古丁和一氧化碳对犬动脉壁对125I标记的纤维蛋白原通透性的影响。结果表明，吸入香烟烟雾会显著且迅速地增加动脉壁对纤维蛋白原的通透性，而且这种作用仅用一氧化碳就能产生，而静脉注射尼古丁则不能。
