Vascular Medicine Department, CHU Rennes, French National Health and Medical Research (Inserm), Clinical Investigation Center (CIC) 1414, University of Rennes 1, Rennes F-35033, France.
NuMeCan Institute, Exogenous and Endogenous Stress and Pathological Responses in Hepato-Gastrointestinal Diseases (EXPRES) Team, French National Health and Medical Research (Inserm) U1241, University of Rennes 1, Rennes F-35033, France.
Aging (Albany NY). 2020 Dec 27;12(24):26263-26278. doi: 10.18632/aging.202422.
Inflammaging constitutes the common factor for comorbidities predisposing to severe COVID-19. Inflammaging leads to T-cell senescence, and immunosenescence is linked to autoimmune manifestations in COVID-19. As in SLE, metabolic dysregulation occurs in T-cells. Targeting this T-cell dysfunction opens the field for new therapeutic strategies to prevent severe COVID-19. Immunometabolism-mediated approaches such as rapamycin, metformin and dimethyl fumarate, may optimize COVID-19 treatment of the elderly and patients at risk for severe disease.
炎症性衰老构成了导致严重 COVID-19 的合并症的共同因素。炎症性衰老导致 T 细胞衰老，而免疫衰老与 COVID-19 中的自身免疫表现有关。与系统性红斑狼疮一样，T 细胞也会出现代谢失调。针对这种 T 细胞功能障碍为预防严重 COVID-19 开辟了新的治疗策略领域。免疫代谢介导的方法，如雷帕霉素、二甲双胍和富马酸二甲酯，可能优化 COVID-19 对老年人和高危疾病患者的治疗。
