Kim Ki Bae, Kim Hyoung Woo, Lee Jun Su, Yoon Soon Man
Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.
Korean J Gastroenterol. 2020 Dec 25;76(6):275-281. doi: 10.4166/kjg.2020.160.
Vitamin D contributes to bone metabolism and acts as an immune modulator for both innate and adaptive immunity. The serum level of vitamin D has been associated with inflammatory diseases, such as inflammatory bowel disease (IBD). In epidemiologic studies, IBD patients have been shown to have low levels of vitamin D. The suboptimal circulating levels of vitamin D in IBD patients may be caused by low exposure to sunlight, dietary malabsorption, and the impaired conversion of active metabolites (1,25[OH]D). Recent studies have demonstrated that vitamin D deficiency in IBD can increase the chance of disease recurrence, IBD-related hospitalization or surgery, and deterioration of quality of life. Supplementation with vitamin D is therefore thought to reduce the risk of flare-ups and the improvement of the quality of life in IBD patients. This review aims to summarize the latest knowledge on the effects of vitamin D deficiency on IBD and the possible benefits of vitamin D supplementation in IBD patients.
维生素D有助于骨骼代谢，并作为先天性和适应性免疫的免疫调节剂。维生素D的血清水平与炎症性疾病有关，如炎症性肠病（IBD）。在流行病学研究中，IBD患者的维生素D水平较低。IBD患者循环维生素D水平不理想可能是由于阳光照射不足、饮食吸收不良以及活性代谢物（1,25[OH]D）转化受损所致。最近的研究表明，IBD患者维生素D缺乏会增加疾病复发、IBD相关住院或手术以及生活质量恶化的几率。因此，补充维生素D被认为可以降低IBD患者病情复发的风险并改善其生活质量。本综述旨在总结维生素D缺乏对IBD影响的最新知识以及补充维生素D对IBD患者可能带来的益处。
