National University of Kyiv-Mohyla Academy, 2 G. Skovorody Str., Kyiv 04070.
Probl Radiac Med Radiobiol. 2020 Dec;25:300-308. doi: 10.33145/2304-8336-2020-25-300-308.
To perform comparative analysis of the characteristics of population functioning process of mice bonemarrow colony-forming units after their prolonged irradiation in lethal and non-lethal doses with equal dose rateintensity with the aid of mathematical model.
Assigned task is solved by means of mathematical model of alterations in the number ofbone marrow colony-forming units after continuous irradiation, described in previous works, with the use of experimental results of K. S. Chertkov works (1972, 1973). Mathematical model is developed basing on the hematopoiesisscheme introduced by I. L. Chertkov (1984, 1991).
By applying original mathematical model, new scheme of hematopoiesis [6], with theuse of experimental results of γ-irradiation influence in the doses of 4 Gy and 8 Gy with the dose rate intensity of0.0028 Gy/min on the number of mice bone marrow colony-forming units, as well as experimental data concerningthe processes of their number recovery, obtained from literature references, we determined the parameters, whichcharacterize hematopoietic system reaction on the different stages of recovery processes of mice bone marrowcolony-forming units after the termination of ionizing radiation action; comparative analysis of obtained resultswas performed.
借助数学模型，对致死和非致死剂量、等剂量率强度下长时间辐射后小鼠骨髓集落形成单位的种群功能过程特征进行比较分析。
利用 K.S.Chertkov 的实验结果（1972 年，1973 年），通过先前工作中描述的连续辐射后骨髓集落形成单位数量变化的数学模型来解决指定任务。数学模型是基于 I.L.Chertkov 提出的造血方案（1984 年，1991 年）开发的。
通过应用原始数学模型和新的造血方案[6]，利用 4Gy 和 8Gy 剂量、0.0028Gy/min 剂量率强度的γ辐射对小鼠骨髓集落形成单位数量的影响的实验结果，以及从文献中获得的关于其数量恢复过程的实验数据，我们确定了参数，这些参数描述了造血系统在终止电离辐射作用后，在不同阶段对小鼠骨髓集落形成单位的恢复过程的反应；对获得的结果进行了比较分析。
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