血小板模拟药物递送纳米粒子增强乳腺癌的化疗-光热治疗。

Platelet-Mimicking Drug Delivery Nanoparticles for Enhanced Chemo-Photothermal Therapy of Breast Cancer.

机构信息

Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People's Republic of China.

Research Center of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People's Republic of China.

出版信息

Int J Nanomedicine. 2020 Dec 14;15:10151-10167. doi: 10.2147/IJN.S285952. eCollection 2020.

BACKGROUND

Traditional nanoparticle-based drug delivery systems suffer from several limitations, such as easy clearance from blood and inaccurate targeting.

MATERIALS AND METHODS

Here, we developed platelet membrane-coated nanoparticles (PM-NPs) to improve the precise delivery of drugs to tumor sites and enable a more efficient photothermal therapy (PTT) treatment.

RESULTS

Mimicking the natural platelet membrane, nanoparticles containing drugs and photothermal agents were not recognized and cleared by the immune system; they could circulate in the blood for a long time and accumulate more efficiently at the tumor site, thus releasing more antitumor drugs and achieving better PTT effects. It is worth mentioning that, in this study, we found that tumors in mice treated with the platelet-mimicking nanoparticles were completely eliminated without recurrence during the observation period (up to 18 days).

CONCLUSION

This study provides a new strategy to design delivery systems of drugs or photothermal agents, whether in biotherapy or other fields.

背景

传统的基于纳米粒子的药物输送系统存在许多局限性，例如容易从血液中清除和靶向不准确。

材料和方法

在这里，我们开发了血小板膜包覆的纳米粒子（PM-NPs），以提高药物对肿瘤部位的精确输送，并实现更有效的光热治疗（PTT）治疗。

结果

模仿天然血小板膜，含有药物和光热剂的纳米粒子不会被免疫系统识别和清除；它们可以在血液中长时间循环，并更有效地在肿瘤部位聚集，从而释放更多的抗肿瘤药物并实现更好的 PTT 效果。值得一提的是，在这项研究中，我们发现，在用血小板模拟纳米粒子治疗的小鼠中，肿瘤在观察期（长达 18 天）内完全消除，没有复发。