中国汉族人群基因多态性与胃癌易感性的病例对照研究

Case-Control Study on Gene Polymorphism and Susceptibility to Gastric Cancer in a Chinese Han Population.

作者信息

Gu Xuyu, Mao Zhenwei, Pan Huiwen, Zou Chen, Ding Guowen, Fan Yu

机构信息

School of Medicine, Southeast University, Nanjing, Jiangsu 210009, People's Republic of China.

Cancer Institute, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu 212002, People's Republic of China.

出版信息

Pharmgenomics Pers Med. 2020 Dec 17;13:749-756. doi: 10.2147/PGPM.S283308. eCollection 2020.

DOI:10.2147/PGPM.S283308

PMID:33363398

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7751833/

Abstract

PURPOSE

To explore the relationship between rs2297440 and rs2297441 polymorphisms of gene and susceptibility to gastric cancer.

METHODS

A hospital-based case-control study was conducted. A total of 577 gastric cancer cases and 678 normal controls were recruited. Their genotypes were determined using the SnapShot method.

RESULTS

The smoking rate in the case group (34.49%) was higher than that in the control group (27.29%). For rs2297440, among people <62 years old, the risk of gastric cancer in TC people was 1.84 times that in TT people. Among the non-drinking people, the risk of gastric cancer in the CC type was 0.66 times that in the TT+TC type. Among the drinking population, the risk of gastric cancer in the TC type was 1.67 times that in the TT type, and the risk in the TC+CC type was 1.70 times that in the TT type. As for rs2297441, in males and non-drinkers, the risk of gastric cancer in the AG type was less than that in the GG type. No matter how old the patient is, the risk of gastric cancer in the AA type was less than that in the AG+GG type.

CONCLUSION

A correlation exists between smoking and gastric cancer. For rs2297440, the TC genotype may be a risk factor for gastric cancer in people <62 years old. In the non-drinking population, the homozygous mutant of CC may be a protective factor for gastric cancer. In the drinking population, TC type may be a risk factor, whereas the TC+CC type dominated by C may be a protective factor. For rs2297441, the AG genotype may be a risk factor for gastric cancer in males and non-drinkers. The AA homozygous mutant may be a protective factor for gastric cancer.

摘要

目的

探讨基因的rs2297440和rs2297441多态性与胃癌易感性之间的关系。

方法

开展一项基于医院的病例对照研究。共招募了577例胃癌病例和678例正常对照。采用荧光微球技术测定他们的基因型。

结果

病例组的吸烟率（34.49%）高于对照组（27.29%）。对于rs2297440，在62岁以下人群中，TC型人群患胃癌的风险是TT型人群的1.84倍。在不饮酒人群中，CC型患胃癌的风险是TT+TC型的0.66倍。在饮酒人群中，TC型患胃癌的风险是TT型的1.67倍，TC+CC型的风险是TT型的1.70倍。至于rs2297441，在男性和不饮酒者中，AG型患胃癌的风险低于GG型。无论患者年龄多大，AA型患胃癌的风险低于AG+GG型。

结论

吸烟与胃癌之间存在相关性。对于rs2297440，TC基因型可能是62岁以下人群患胃癌的危险因素。在不饮酒人群中，CC的纯合突变可能是胃癌的保护因素。在饮酒人群中，TC型可能是危险因素，而以C为主的TC+CC型可能是保护因素。对于rs2297441，AG基因型可能是男性和不饮酒者患胃癌的危险因素。AA纯合突变可能是胃癌的保护因素。