Hernández Micaela Anahi, Chaves Hernán, Allegri Ricardo Francisco, Calandri Ismael Luis
Fleni, Department of Cognitive Neurology, Buenos Aires, Argentina.
Fleni, Diagnostic Imaging Department, Buenos Aires, Argentina.
Dement Neuropsychol. 2024 Nov 11;18:e20240163. doi: 10.1590/1980-5764-DN-2024-0163. eCollection 2024.
Transient global amnesia (TGA) is a rare, temporary, sudden-onset disturbance in anterograde episodic memory with unclear pathophysiology. Previous brain volumetric analysis in TGA patients showed varied results.
To explore brain morphometry, hypothesizing that patients with TGA exhibit structural alterations.
A case-control study was performed involving TGA subjects (n=50) and matched healthy controls (n=50). Both groups underwent a 3D-T1 weighted structural MRI on a 3T scanner, and voxel-based morphometry (VBM), region-based morphometry (RBM), and surface-based morphometry (SBM) were analyzed.
After performing the VBM, RBM, and SBM analyses, no consistent and statistically significant differences were found after applying multiple corrections.
Despite previous studies showing volumetric changes in TGA patients, our results differ from this. The discrepancy could be due to sample size and timing of MRI scans. While our findings do not explain TGA pathophysiology, they support a network dysfunction as a possible mechanism and discards a structural alteration as a predisposing factor for TGA.
短暂性全面性遗忘症（TGA）是一种罕见的、暂时性的、突然发作的顺行性情景记忆障碍，其病理生理学尚不清楚。先前对TGA患者进行的脑容积分析结果各异。
探讨脑形态学，假设TGA患者存在结构改变。
进行一项病例对照研究，纳入TGA受试者（n = 50）和匹配的健康对照者（n = 50）。两组均在3T扫描仪上进行三维T1加权结构磁共振成像（MRI），并分析基于体素的形态学测量（VBM）、基于区域的形态学测量（RBM）和基于表面的形态学测量（SBM）。
进行VBM、RBM和SBM分析后，在应用多重校正后未发现一致且具有统计学意义的差异。
尽管先前的研究表明TGA患者存在容积变化，但我们的结果与之不同。这种差异可能归因于样本量和MRI扫描时间。虽然我们的研究结果无法解释TGA的病理生理学，但它们支持网络功能障碍作为一种可能的机制，并排除了结构改变作为TGA的 predisposing因素。 （注：predisposing 这个词可能有误，推测可能是“predisposing”，意为“ predisposing”，“使易患；使倾向于” ，这里结合语境可能想表达“诱发因素”之类的意思，但原文这个词不太准确完整，翻译存疑）
