Lee Dong Ah, Lee Ho-Joon, Park Kang Min
From the Department of Neurology (D.A.L., K.M.P.), Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
Department of Radiology (H.-J.L.), Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
AJNR Am J Neuroradiol. 2025 Apr 2;46(4):675-680. doi: 10.3174/ajnr.A8530.
The peak width of skeletonized mean diffusivity (PSMD) is a novel marker of small vessel disease. In this study, we aimed to investigate the presence of small vessel disease in patients with transient global amnesia (TGA) by using the PSMD.
We enrolled 75 patients newly diagnosed with TGA and included 65 age- and sex-matched healthy controls. DTI was performed by using a 3T MR imaging scanner. We measured the PSMD based on DTI by using the FSL program. This measure was compared between patients with TGA and healthy controls. Additionally, we conducted a correlation analysis to explore the relationship between PSMD and clinical factors.
A significant difference in the PSMD between patients with TGA and healthy controls was observed. Patients with TGA exhibited higher a PSMD compared with healthy controls (2.297 ± 0.232 versus 2.188 ± 0.216 × 10 mm/s, = .005). Additionally, patients with TGA but without any vascular risk factors, such as diabetes, hypertension, or dyslipidemia, also exhibited higher a PSMD compared with healthy controls (2.278 ± 0.253 versus 2.188 ± 0.216 × 10 mm/s, = .036). The PSMD positively correlated with age ( = 0.248, = .032); however, it was not associated with duration of amnesia.
This finding underscores the feasibility of using PSMD as a marker for detecting small vessel diseases in patients with neurologic disorders. Furthermore, our study also implies the presence of small vessel disease may be present in patients with TGA.
骨骼化平均扩散率的峰宽（PSMD）是小血管疾病的一种新型标志物。在本研究中，我们旨在通过使用PSMD来调查短暂性全面性遗忘症（TGA）患者中小血管疾病的存在情况。
我们纳入了75例新诊断为TGA的患者，并纳入了65例年龄和性别匹配的健康对照。使用3T磁共振成像扫描仪进行弥散张量成像（DTI）。我们使用FSL程序基于DTI测量PSMD。在TGA患者和健康对照之间比较了这一指标。此外，我们进行了相关性分析以探讨PSMD与临床因素之间的关系。
观察到TGA患者和健康对照之间的PSMD存在显著差异。与健康对照相比，TGA患者的PSMD更高（2.297±0.232对2.188±0.216×10 mm/s，P = 0.005）。此外，与健康对照相比，没有任何血管危险因素（如糖尿病、高血压或血脂异常）的TGA患者的PSMD也更高（2.278±0.253对2.188±0.216×10 mm/s，P = 0.036）。PSMD与年龄呈正相关（r = 0.248，P = 0.032）；然而，它与遗忘持续时间无关。
这一发现强调了使用PSMD作为检测神经系统疾病患者中小血管疾病标志物的可行性。此外，我们的研究还表明TGA患者中可能存在小血管疾病。
