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中毒性表皮坏死松解症患者的严重程度及可预防性分析——病例系列

Analysis of severity and preventability in patients of-Toxic epidermal necrolysis-A case series.

作者信息

Ciddhavaduta Deepa Latha, Kalaiselvan Vivekanandan, Midde Madhavi Latha, Baloju Deepika

机构信息

Department of Pharmacology Santhiram Medical College Nandyal India.

Indian Pharmacopoeia Commission Ministry of Health and Family Welfare Ghaziabad India.

出版信息

Clin Case Rep. 2020 Jul 28;8(12):2452-2456. doi: 10.1002/ccr3.3145. eCollection 2020 Dec.

DOI:10.1002/ccr3.3145
PMID:33363758
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7752467/
Abstract

SJS-TEN is life-threatening autoimmune disorder triggered due to drugs such as analgesics, antibiotics, anticonvulsants, and antipsychotics. This report provides awareness to the Clinicians regarding prescription of drugs which cause SJS-TEN. Among young females of 20-40 years, screening for previous history, issuing drug alert cards, and preventing OTC prescriptions decreases mortality.

摘要

史蒂文斯-约翰逊综合征-中毒性表皮坏死松解症（SJS-TEN）是一种由镇痛药、抗生素、抗惊厥药和抗精神病药等药物引发的危及生命的自身免疫性疾病。本报告旨在提高临床医生对可导致SJS-TEN的药物处方的认识。在20至40岁的年轻女性中，筛查既往病史、发放药物警示卡以及避免非处方用药可降低死亡率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f70/7752467/4e5f18119ac2/CCR3-8-2452-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f70/7752467/43da254ad779/CCR3-8-2452-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f70/7752467/7b1056868e1e/CCR3-8-2452-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f70/7752467/4e5f18119ac2/CCR3-8-2452-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f70/7752467/43da254ad779/CCR3-8-2452-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f70/7752467/7b1056868e1e/CCR3-8-2452-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f70/7752467/4e5f18119ac2/CCR3-8-2452-g003.jpg

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本文引用的文献

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Eur J Clin Pharmacol. 2019 Aug;75(8):1135-1141. doi: 10.1007/s00228-019-02670-9. Epub 2019 Mar 27.
2
Study on the Classification, Causality, Preventability and Severity of Adverse Drug Reaction Using Spontaneous Reporting System in Hospitalized Patients.利用医院住院患者自发报告系统对药品不良反应的分类、因果关系、可预防性及严重程度的研究
Pharmacy (Basel). 2018 Sep 29;6(4):108. doi: 10.3390/pharmacy6040108.
3
The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in the UK.
英国史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症的流行病学
J Invest Dermatol. 2017 Jun;137(6):1240-1247. doi: 10.1016/j.jid.2017.01.031. Epub 2017 Feb 12.
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Antiepileptic Drugs-induced Stevens-Johnson syndrome: A case Series.抗癫痫药物所致史蒂文斯-约翰逊综合征：病例系列
J Basic Clin Pharm. 2016 Dec;8(1):42-44. doi: 10.4103/0976-0105.195130.
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