Yang Daniel D, Paterna Nicholas J, Senetra Alexandria S, Casey Kaitlyn R, Trieu Phillip D, Caputo Gregory A, Vaden Timothy D, Carone Benjamin R
Department of Chemistry and Biochemistry, Rowan University, 201 Mullica Hill Road, Glassboro, NJ 08028, USA.
Department of Molecular and Cellular Biosciences, Rowan University, 201 Mullica Hill Road, Glassboro, NJ 08028, USA.
iScience. 2020 Nov 23;24(1):101853. doi: 10.1016/j.isci.2020.101853. eCollection 2021 Jan 22.
Combinations of ionic liquids (ILs) with antimicrobial compounds have been shown to produce synergistic activities in model liposomes. In this study, imidazolium chloride-based ILs with alkyl tail length variations are combined with commercially available, small-molecule antimicrobials to examine the potential for combinatorial and synergistic antimicrobial effects on and The effects of these treatments in a human cell culture model indicate the cytotoxic limits of ILs paired with antimicrobials. The analysis of these ILs demonstrates that the length of the alkyl chain on the IL molecule is proportional to both antimicrobial activity and cytotoxicity. Moreover, the ILs which exhibit synergy with small-molecule antibiotics appear to be acting in a membrane permeabilizing manner. Collectively, results from these experiments demonstrate an increase in antimicrobial efficacy with specific IL + antimicrobial combinations on microbial cultures while maintaining low cytotoxicity in a mammalian cell culture model.
离子液体（ILs）与抗菌化合物的组合已被证明在模型脂质体中产生协同活性。在本研究中，具有不同烷基链长度的基于氯化咪唑鎓的离子液体与市售小分子抗菌剂相结合，以研究其对[具体对象1]和[具体对象2]的组合抗菌和协同抗菌作用潜力。这些处理在人类细胞培养模型中的效果表明了与抗菌剂配对的离子液体的细胞毒性限度。对这些离子液体的分析表明，离子液体分子上烷基链的长度与抗菌活性和细胞毒性均成正比。此外，与小分子抗生素表现出协同作用的离子液体似乎以膜通透的方式起作用。总体而言，这些实验结果表明，特定的离子液体+抗菌剂组合在微生物培养物上的抗菌效果增强，同时在哺乳动物细胞培养模型中保持低细胞毒性。
