Abdel-Azeem H H, Osman G Y, El Garhy M F, Al Benasy K S
Department of Zoology, Menoufia University, Shebeen El-koom, Egypt.
Department of Zoology, Cairo University, Giza, Egypt.
Helminthologia. 2020 Nov 19;57(4):335-343. doi: 10.2478/helm-2020-0037. eCollection 2020 Dec.
snails have received much attention due to their great medical importance as vectors for transmitting infection to humans. The main objective of the present work was to assess the efficacy of miltefosin a synthetic molluscicidal drug and artemether a natural molluscicidal drug. The correlation between immunological and histological observations from light and electron microscopy of the hemocytes of post treatment with both drugs was also evaluated. LC and LC values were represented by 13.80 ppm and 24.40 ppm for miltefosine and 16.88 ppm and 27.97 ppm for artemether, respectively. The results showed that the treatment of -infected snails and normal snails with sublethal dose of miltefosine (LC8.20 ppm) and artemether (LC11.04 ppm) induced morphological abnormalities and a significant reduction in hemocytes count.
蜗牛作为将感染传播给人类的媒介，因其具有重大医学重要性而备受关注。本研究的主要目的是评估合成杀螺药物米替福新和天然杀螺药物蒿甲醚的疗效。还评估了两种药物处理后，通过光镜和电镜对血细胞进行免疫和组织学观察之间的相关性。米替福新的LC和LC值分别为13.80 ppm和24.40 ppm，蒿甲醚的LC和LC值分别为16.88 ppm和27.97 ppm。结果表明，用亚致死剂量的米替福新（LC8.20 ppm）和蒿甲醚（LC11.04 ppm）处理感染的蜗牛和正常蜗牛，会导致形态异常和血细胞数量显著减少。
