青蒿素对曼氏血吸虫病小鼠细胞因子谱和虫卵诱导病理学的影响。
Effect of artemether on cytokine profile and egg induced pathology in murine schistosomiasis mansoni.
机构信息
Zoology Department, Faculty of Science, Cairo University, Egypt.
Theodore Bilharz Research Institute, Giza, Egypt.
出版信息
J Adv Res. 2015 Nov;6(6):851-7. doi: 10.1016/j.jare.2014.07.003. Epub 2014 Jul 29.
Artemether (ART), the methylated derivative of artemisinin, is an efficacious antimalarial drug that also displays antischistosomal properties. This study was designed to evaluate the immunomodulatory action of a single intramuscular dose (50 mg/kg body weight) of ART in comparison with PZQ treatment (42 days PI). ART administration was 7, 14, 21 and 45 days PI. ART effect was studied parasitologically, histopathologically and immunologically. It was found that maximum effect was reached when ART treatment interfered with 14 or 21 days old schistosomula. ART treatment 14 or 21 days PI was associated with shift from Th2 to Th1 predominancy (decrease in IL-4 and upgrading of serum IFN-γ levels). In conclusion, ART is a promising drug in control of schistosomiasis mansoni due to its reductive effect on worm burden and its role in improvement of hepatic granulomatous lesions.
蒿甲醚（ART）是青蒿素的甲基衍生物，是一种有效的抗疟药物，也具有抗血吸虫病的特性。本研究旨在评估单次肌肉注射（50mg/kg 体重）ART 的免疫调节作用，并与 PZQ 治疗（PI 后 42 天）进行比较。ART 给药时间为 PI 后 7、14、21 和 45 天。从寄生虫学、组织病理学和免疫学方面研究了 ART 的作用。结果发现，当 ART 治疗作用于 14 或 21 天龄的血吸虫幼体时，效果达到最大。PI 后 14 或 21 天的 ART 治疗与 Th2 向 Th1 优势的转变相关（IL-4 减少和血清 IFN-γ 水平升高）。总之，由于 ART 对虫荷的减少作用及其在改善肝肉芽肿病变中的作用，ART 是控制曼氏血吸虫病的一种有前途的药物。
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