Jacob Joanne S, Cohen Philip R
Medicine, Baylor College of Medicine, Houston, USA.
Dermatology, San Diego Family Dermatology, National City, USA.
Cureus. 2020 Nov 18;12(11):e11546. doi: 10.7759/cureus.11546.
Antibiotics have been observed to cause drug-induced reactions. These can include a cutaneous adverse reaction to the drug (CARD) such as photosensitivity. A 51-year-old woman initiated doxycycline monohydrate for rosacea. Within nine days, she developed two different, simultaneous skin rashes: a phototoxic reaction and a morbilliform drug eruption. The medication was stopped; topical and oral corticosteroids were initiated. Within two weeks, her rashes resolved. Common cutaneous adverse reactions to doxycycline include photosensitivity and morbilliform exanthem. Less common skin side effects include bullous eruptions, lupus-like eruptions, pigmentary disorders, and vasculitis. Albeit uncommon, doxycycline-associated dual CARD - such as the photosensitivity and morbilliform exanthem - may occur.
已观察到抗生素会引起药物不良反应。这些不良反应可包括对药物的皮肤不良反应（CARD），如光敏反应。一名51岁女性开始服用一水合多西环素治疗酒渣鼻。九天内，她同时出现了两种不同的皮疹：光毒性反应和麻疹样药疹。停用了该药物；开始使用局部和口服皮质类固醇。两周内，她的皮疹消退。多西环素常见的皮肤不良反应包括光敏反应和麻疹样皮疹。较不常见的皮肤副作用包括大疱性皮疹、狼疮样皮疹、色素沉着紊乱和血管炎。尽管不常见，但多西环素相关的双重CARD，如光敏反应和麻疹样皮疹，仍可能发生。
