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一例罕见的度拉糖肽相关性麻疹样药疹病例。

An Uncommon Case of Dulaglutide-Related Morbilliform Drug Eruption.

作者信息

Kyriakos Georgios, Diamantis Evangelos, Memi Eleni, Elefsiniotis Ioannis

机构信息

Endocrinology and Nutrition Section, Hospital General Universitario Santa Lucía, Cartagena, ESP.

Academic Department of Internal Medicine - Endocrinology Unit, General Oncology Hospital of Kifisia "Agioi Anargyroi" National and Kapodistrian University of Athens, Athens, GRC.

出版信息

Cureus. 2022 Jan 23;14(1):e21536. doi: 10.7759/cureus.21536. eCollection 2022 Jan.

Abstract

Dulaglutide is a once-weekly injectable glucagon-like peptide-1 (GLP-1) receptor agonist that has shown a durable glycemic efficacy as well as beneficial effects on body weight and major adverse cardiovascular events (MACE) outcomes, making it an important option for the treatment of type 2 diabetes. Common side effects of dulaglutide include nausea, diarrhea, and abdominal distension, and these are usually mild to moderate in severity and tend to diminish over time. Morbilliform drug eruptions to dulaglutide are very rare, with only one case reported until now. We report another case of dulaglutide-morbilliform drug eruption to alert the attending physicians that dulaglutide-related adverse skin reactions should be kept in mind as generalized use of dulaglutide and other GLP-1 receptor agonists are expected to remain in widespread clinical use in the future.

摘要

度拉糖肽是一种每周注射一次的胰高血糖素样肽-1(GLP-1)受体激动剂,已显示出持久的血糖控制效果以及对体重和主要不良心血管事件(MACE)结局的有益影响,使其成为治疗2型糖尿病的重要选择。度拉糖肽的常见副作用包括恶心、腹泻和腹胀,这些副作用通常为轻至中度,且往往会随着时间的推移而减轻。度拉糖肽引起的麻疹样药疹非常罕见,迄今为止仅报告过1例。我们报告了另一例度拉糖肽引起的麻疹样药疹,以提醒主治医生,随着度拉糖肽和其他GLP-1受体激动剂有望在未来继续广泛应用于临床,应牢记与度拉糖肽相关的皮肤不良反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/183f/8864188/0856c16d6e33/cureus-0014-00000021536-i01.jpg

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