新冠患者营养状况与预后的相关性分析。
A Correlation Analysis between the Nutritional Status and Prognosis of COVID-19 Patients.
机构信息
Yi Ma, Department of Emergency, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China,
出版信息
J Nutr Health Aging. 2021;25(1):84-93. doi: 10.1007/s12603-020-1457-6.
PURPOSE
The present study investigated the correlation between the nutritional status and prognosis of COVID-19 patients, and analyzed the epidemiological characteristics of COVID-19 patients with different nutritional status.
METHODS
429 patients who were diagnosed positive for COVID-19 in Hubei Provincial Hospital of Traditional Chinese Medicine from December 2019 to March 2020 were selected and divided into different groups based on Controlling Nutritional Status (CONUT) score (0-4: the low CONUT score group; 5-12: the high CONUT score group). Multivariate logistic regression analysis was applied to investigate the effects of CONUT score on prognosis.
RESULTS
The total score of admission status of patients with higher CONUT score was higher than that of those with lower CONUT score (χ2 = 7.152, P = 0.007). The number of adverse outcomes of female was higher than that of male (χ2 = 10.253, P = 0.001). The number of adverse outcomes was higher for patients with smoking history (P = 0.004) or hypertension (χ2 = 11.240, P = 0.001) than those without. Also, the number of adverse outcomes was higher for older patients than younger ones (χ2 = 15.681, P < 0.001). Patients with adverse outcomes had lower urine red blood cell count than patients without adverse outcomes (χ2 = 5.029, P = 0.025). However, BMI, drinking history and diabetes did not show correlation with the prognosis of COVID-19 (P > 0.05).Among patients ≥ 61 years old, the risk of adverse outcomes in the high CONUT score group was 6.191 times that of the low CONUT score group (OR = 6.191, 95% CI: 1.431-26.785).Among the non-diabetic patients, the risk of adverse outcomes in the high CONUT group was 11.678 times that of the low CONUT group (OR = 11.678, 95% CI: 2.754-49.41).For the patients who had a total score of admission status < 6, the risk of adverse outcomes in the high CONUT score group was 8.216 times that of the low CONUT score group (OR = 8.216, 95% CI: 2.439-27.682).
CONCLUSION
COVID-19 patients with good nutritional status showed a small chance to have adverse outcomes. Gender, age, hypertension, the number of urine red blood cell count and CONUT score affected the adverse outcomes of patients.
目的
本研究旨在探讨 COVID-19 患者营养状况与预后的相关性，并分析不同营养状况 COVID-19 患者的流行病学特征。
方法
选取 2019 年 12 月至 2020 年 3 月在湖北省中医院确诊为 COVID-19 的 429 例患者，根据控制营养状况（CONUT）评分（0-4：低 CONUT 评分组；5-12：高 CONUT 评分组）将患者分为不同组。采用多变量逻辑回归分析探讨 CONUT 评分对预后的影响。
结果
高 CONUT 评分组患者入院时的总评分高于低 CONUT 评分组（χ2 = 7.152，P = 0.007）。女性不良结局的例数高于男性（χ2 = 10.253，P = 0.001）。有吸烟史（P = 0.004）或高血压史（χ2 = 11.240，P = 0.001）的患者不良结局例数高于无上述病史的患者。此外，年龄较大的患者不良结局例数高于年龄较小的患者（χ2 = 15.681，P < 0.001）。不良结局患者的尿红细胞计数低于无不良结局患者（χ2 = 5.029，P = 0.025）。然而，BMI、饮酒史和糖尿病与 COVID-19 的预后无关（P > 0.05）。≥ 61 岁的患者中，高 CONUT 评分组不良结局的风险是低 CONUT 评分组的 6.191 倍（OR = 6.191，95%CI：1.431-26.785）。在非糖尿病患者中，高 CONUT 组不良结局的风险是低 CONUT 组的 11.678 倍（OR = 11.678，95%CI：2.754-49.41）。对于入院时总评分<6 的患者，高 CONUT 评分组不良结局的风险是低 CONUT 评分组的 8.216 倍（OR = 8.216，95%CI：2.439-27.682）。
结论
营养状况良好的 COVID-19 患者发生不良结局的几率较小。性别、年龄、高血压、尿红细胞计数和 CONUT 评分影响患者的不良结局。
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