Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands.
Biochem Soc Trans. 2021 Feb 26;49(1):341-352. doi: 10.1042/BST20200670.
Coronaviruses (CoV) are positive-sense single-stranded RNA viruses, harboring the largest viral RNA genomes known to date. Apart from the primary sequence encoding for all the viral proteins needed for the generation of new viral particles, certain regions of CoV genomes are known to fold into stable structures, controlling several aspects of CoV life cycle, from the regulation of the discontinuous transcription of subgenomic mRNAs, to the packaging of the genome into new virions. Here we review the current knowledge on CoV RNA structures, discussing it in light of the most recent discoveries made possible by analyses of the SARS-CoV-2 genome.
冠状病毒（CoV）是正链单链 RNA 病毒，拥有迄今为止已知的最大病毒 RNA 基因组。除了编码所有用于生成新病毒颗粒的病毒蛋白的主要序列外，CoV 基因组的某些区域已知折叠成稳定的结构，控制着 CoV 生命周期的几个方面，从亚基因组 mRNA 的不连续转录调控到基因组包装到新的病毒粒子中。在这里，我们回顾了 CoV RNA 结构的现有知识，并结合对 SARS-CoV-2 基因组分析所取得的最新发现进行了讨论。
