Holt S C, Ebersole J, Felton J, Brunsvold M, Kornman K S
Department of Periodontics, University of Texas Health Science Center at San Antonio 78284.
Science. 1988 Jan 1;239(4835):55-7. doi: 10.1126/science.3336774.
Although periodontitis is a bacterial disease, its multidimensional nature and its bacterial complexity have made it difficult to definitively prove that specific microorganisms initiate the disease process. The successful implantation of a rifampin-resistant strain of the putative periodontal pathogen Bacteroides gingivalis into the periodontal microbiota of monkeys (Macaca fascicularis) resulted in an increase in the systemic levels of antibody to the microorganism and rapid and significant bone loss.
尽管牙周炎是一种细菌性疾病，但其多维度性质和细菌复杂性使得难以确凿证明特定微生物引发了疾病进程。将推定的牙周病原体牙龈卟啉单胞菌的耐利福平菌株成功植入猕猴（食蟹猴）的牙周微生物群中，导致针对该微生物的抗体全身水平升高以及快速且显著的骨质流失。
