Linking Periodontitis with Inflammatory Bowel Disease through the Oral-Gut Axis: The Potential Role of .

Periodontitis and inflammatory bowel disease (IBD) are both chronic inflammatory diseases that are characterized by abnormal host immune responses and microbiota dysbiosis. Emerging evidence implies potential associations between periodontitis and IBD. (), a primary cause of periodontitis, is thought to play a role in the development of IBD through the oral-gut disease axis. However, the precise mechanisms of its involvement remain enigmatic. In this narrative review, we begin with a discussion of the bidirectional relationship between periodontitis and IBD and the involvement of in each of the two diseases. Further, we summarize the possible routes by which links periodontitis and IBD through the oral-gut axis, as well as the underlying mechanisms of its involvement in the pathogenesis of IBD. Collectively, participates in the progression of IBD through gut dysbiosis, impairment of the intestinal barrier, release of inflammatory mediators, and disturbance of the immune response. The above findings may provide new insights for exploring novel biomarkers and potential therapeutic approaches for IBD.