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全基因组测序提示两例肾移植受者感染人型支原体，感染源自同一供者。

Unexpected Mycoplasma hominis infection in two renal transplant recipients traced back to the same donor by whole-genome sequencing.

机构信息

Division of Clinical Bacteriology and Mycology, University Hospital Basel, Basel, Switzerland.

Applied Microbiology Research, Department of Biomedicine, University of Basel, Basel, Switzerland.

出版信息

Eur J Clin Microbiol Infect Dis. 2021 May;40(5):1097-1102. doi: 10.1007/s10096-020-04116-y. Epub 2020 Dec 23.

DOI:10.1007/s10096-020-04116-y
PMID:33367958
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8084823/
Abstract

Mycoplasma hominis is a common colonizer of the lower genitourinary tract. Although its clinical relevance for causing urogenital infections in immunocompetent individuals is controversial, this bacterium has been involved in severe invasive infections in allograft recipients. In this report, we describe two cases of M. hominis infection in two young renal transplant recipients within the first month post-transplant. Although at first no epidemiological link between the two cases had been suspected, whole-genome sequencing (WGS) analysis showed that both isolates were identical, highly suggestive of an origin with the common organ donor.

摘要

人型支原体是下泌尿生殖道的常见定植菌。虽然其在免疫功能正常个体中引起泌尿生殖道感染的临床相关性存在争议，但该细菌已参与同种异体移植受者的严重侵袭性感染。在本报告中，我们描述了两名年轻肾移植受者在移植后第一个月内发生的两例人型支原体感染。尽管最初并未怀疑这两例之间存在流行病学联系，但全基因组测序（WGS）分析表明，两个分离株完全相同，强烈提示与共同器官供体起源有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9c0/8084823/b9af4588a984/10096_2020_4116_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9c0/8084823/642231ec2b3e/10096_2020_4116_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9c0/8084823/766aaba397fe/10096_2020_4116_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9c0/8084823/b9af4588a984/10096_2020_4116_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9c0/8084823/642231ec2b3e/10096_2020_4116_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9c0/8084823/766aaba397fe/10096_2020_4116_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9c0/8084823/b9af4588a984/10096_2020_4116_Fig3_HTML.jpg

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