Federal Research Center Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia.
International Tomography Center, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia.
Dokl Biochem Biophys. 2020 Nov;495(1):319-324. doi: 10.1134/S1607672920060095. Epub 2020 Dec 25.
In recent years, silicon dioxide nanoparticles have been widely used in medicine and the pharmaceutical industry, however, their effect on the brain has hardly been studied. We assessed the effects of long-term consumption of 5-nm amorphous silicon dioxide nanoparticles (SiO-NPs) by Syrian hamsters infected with the trematodes Opisthorchis felineus on the hippocampus and frontal cortex. Spectroscopic determination of brain neurometabolites, performed using a horizontal Magnetic Resonance Imaging system at 11.7 Tesla magnetic field, has shown that the ratio of the excitatory neurotransmitters (glutamate + glutamine + aspartate) to the inhibitory ones (GABA + glycine) was higher in the animals infected with O. felineus. However, pre-consumption of the SiO-NPs solution prevented this imbalance. In addition, the protective effect of SiO-NPs on the level of myo-inositol and glycine was found. It is concluded that the use of SiO-NPs can neutralize the negative effects of infectious factors on the brain.
近年来，二氧化硅纳米粒子在医学和制药行业得到了广泛应用，但它们对大脑的影响几乎没有被研究过。我们评估了长期摄入 5nm 无定形二氧化硅纳米粒子（SiO-NPs）对感染后睾吸虫的叙利亚仓鼠的海马体和额叶皮层的影响。使用磁场强度为 11.7 特斯拉的水平磁共振成像系统进行脑神经代谢物的光谱测定，结果表明，感染后睾吸虫的动物的兴奋性神经递质（谷氨酸+谷氨酰胺+天冬氨酸）与抑制性神经递质（GABA+甘氨酸）的比值更高。然而，SiO-NPs 溶液的预先摄入可以防止这种失衡。此外，还发现 SiO-NPs 对肌醇和甘氨酸水平具有保护作用。因此，可以得出结论，使用 SiO-NPs 可以中和感染因素对大脑的负面影响。
