Department of Stomatology, Lishui Central Hospital of Zhejiang Province, Lishui, 323000, Zhejiang, China.
Department of Infectious Diseases, Lishui Central Hospital of Zhejiang Province, Lishui, 323000, Zhejiang, China.
Microb Pathog. 2020 Jun;143:104113. doi: 10.1016/j.micpath.2020.104113. Epub 2020 Mar 1.
Tumor necrosis factor-α (TNF-α) polymorphisms might influence predisposition to periodontitis, but the results of already published studies were still controversial and ambiguous. So the authors designed this meta-analysis to more precisely estimate relationship between TNF-α polymorphisms and periodontitis by pooling the results of already published related studies.
The authors searched Pubmed, Embase, Web of Science and CNKI for already published studies. Forty-five already published studies were pooled analyzed in this meta-analysis.
The crude pooled meta-analyses results showed that distributions of TNF-α rs361525, rs1800629, rs1800630 and rs1799964 polymorphisms among patients and controls differed significantly, which suggested that these polymorphisms might influence predisposition to periodontitis in the general population. We also got similar significant results for rs361525, rs1800629, rs1800630 and rs1799964 polymorphisms in subgroup analyses in Asians. The crude findings were further subjected to Bonferroni correction to account for multiple comparisons. For rs361525, rs1800629 and rs1799964 polymorphisms, basically no changes of results were detected. But for rs1800630 polymorphism, the results were no longer significant after adjustment for multiple comparisons.
This meta-analysis suggested that TNF-α rs361525, rs1800629 and rs1799964 polymorphisms might influence predisposition to periodontitis, particularly in Asians.
肿瘤坏死因子-α（TNF-α）多态性可能影响牙周炎的易感性，但已发表的研究结果仍存在争议和不明确。因此，作者设计了这项荟萃分析，通过合并已发表的相关研究结果，更准确地评估 TNF-α 多态性与牙周炎之间的关系。
作者检索了 Pubmed、Embase、Web of Science 和中国知网（CNKI），以获取已发表的相关研究。对 45 项已发表的研究进行了荟萃分析。
未校正的荟萃分析结果显示，TNF-α rs361525、rs1800629、rs1800630 和 rs1799964 多态性在病例组和对照组中的分布存在显著差异，这表明这些多态性可能影响一般人群中牙周炎的易感性。我们在亚洲人群的亚组分析中也得到了 rs361525、rs1800629、rs1800630 和 rs1799964 多态性的类似显著结果。未校正的发现进一步通过 Bonferroni 校正进行了多重比较校正。对于 rs361525、rs1800629 和 rs1799964 多态性，结果基本没有变化。但对于 rs1800630 多态性，在进行多重比较校正后，结果不再显著。
这项荟萃分析表明，TNF-α rs361525、rs1800629 和 rs1799964 多态性可能影响牙周炎的易感性，尤其是在亚洲人群中。
