Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospitals, Philadelphia, Pennsylvania, U.S.A.
Sidney Kimmel Medical College, Thomas Jefferson University Hospitals, Philadelphia, Pennsylvania, U.S.A.
Laryngoscope. 2021 Jul;131(7):E2212-E2221. doi: 10.1002/lary.29339. Epub 2020 Dec 25.
OBJECTIVES/HYPOTHESIS: To describe multidimensional quality of life (QOL) outcomes in patients with sinonasal malignancies (SNM). To elucidate factors predicting worse QOL in this population.
Retrospective chart review at tertiary institution.
A retrospective chart review on patients treated for SNM from 2006 to 2019 at a tertiary medical center was conducted. QOL outcomes were measured using the Hospital Anxiety and Depression Scale (HADS) and the Functional Assessment Cancer Therapy - Nasopharynx (FACT-NP) score. A stepwise multiple linear regression analysis was conducted to assess factors predicting worse QOL.
Eighty-one patients met inclusion criteria. Twelve (14.8%) patients had a subscale score >11 for anxiety (HADS-A) or depression (HADS-D) indicating significant anxiety or depression, at a median of 24 (8-68.5) months post treatment. The median FACT-NP total score was 136 (110-152). On multivariable analysis, advanced T classification, single status, and worse social support survey score were significant predictors of worse HADS score. Worse social support survey score was a significant predictor of worse total FACT-NP score.
After adjusting for confounders, at a median of 24 months after completion of definitive therapy for SNM, advanced T classification and single relationship status were found to be significant predictors of anxiety and depression (based on HADS). A worse social support survey score was associated with worse anxiety, depression, and QOL (based on HADS and FACT-NP). Identifying these factors early may help to guide treatment and psychiatric referral to at-risk individuals after the treatment of SNM.
3 Laryngoscope, 131:E2212-E2221, 2021.
目的/假设：描述鼻-鼻窦恶性肿瘤（SNM）患者的多维生活质量（QOL）结果。阐明预测该人群 QOL 更差的因素。
在三级机构进行的回顾性图表审查。
对 2006 年至 2019 年在一家三级医疗中心接受 SNM 治疗的患者进行了回顾性图表审查。使用医院焦虑和抑郁量表（HADS）和癌症治疗功能评估-鼻咽（FACT-NP）评分来衡量 QOL 结果。进行逐步多元线性回归分析以评估预测 QOL 更差的因素。
81 名患者符合纳入标准。12 名（14.8%）患者的焦虑（HADS-A）或抑郁（HADS-D）亚量表评分>11，表明存在明显的焦虑或抑郁，中位数为治疗后 24（8-68.5）个月。FACT-NP 总分中位数为 136（110-152）。多元分析显示，T 期较晚、单身和较差的社会支持调查评分是 HADS 评分较差的显著预测因素。较差的社会支持调查评分是 FACT-NP 总分较差的显著预测因素。
在调整混杂因素后，在 SNM 根治性治疗完成后的中位数 24 个月时，发现 T 期较晚和单身关系状态是焦虑和抑郁（基于 HADS）的显著预测因素。较差的社会支持调查评分与焦虑、抑郁和 QOL（基于 HADS 和 FACT-NP）较差相关。早期识别这些因素可能有助于指导 SNM 治疗后高危个体的治疗和精神科转诊。
3 级喉镜，131：E2212-E2221，2021。
