Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Immunol Rev. 2021 Jan;299(1):74-92. doi: 10.1111/imr.12939. Epub 2020 Dec 23.
Tumorigenesis proceeds through discrete steps where acquisition of genetic lesions and changes in the surrounding microenvironment combine to drive unrestricted neoplastic proliferation and metastasis. The ability of tumor-infiltrating immune cells to promote tumor growth via the provision of signals that enable tumor cell survival and proliferation as well as contribute to immune suppression is an active area of research. Recent efforts have provided us with mechanistic insights into how B cells can positively and negatively regulate immune responses. Negative regulation of immune responses in cancer can be mediated by regulatory B cells and is often a result of increased production of cytokines that can directly and indirectly affect anti-tumor immune function and cancer cell growth. Signals that lead to the expansion of regulatory B cells and the spectrum of their functional roles are not well understood and are the subject of active research by many groups. Here, we elaborate broadly on the history of regulatory B cells in cancer and summarize recent studies that have established genetic models for the study of regulatory B cell function and their potential for therapeutic intervention in the setting of solid cancers.
肿瘤发生是通过离散的步骤进行的，在此过程中，遗传损伤的获得和周围微环境的变化结合在一起，导致不受限制的肿瘤增殖和转移。浸润肿瘤的免疫细胞通过提供促进肿瘤细胞存活和增殖的信号的能力，并有助于免疫抑制，这是一个活跃的研究领域。最近的研究为我们提供了关于 B 细胞如何积极和消极地调节免疫反应的机制见解。在癌症中，免疫反应的负调节可以由调节性 B 细胞介导，并且通常是由于能够直接和间接影响抗肿瘤免疫功能和癌细胞生长的细胞因子的产量增加而导致的。导致调节性 B 细胞扩增及其功能作用范围的信号尚不清楚，许多研究小组正在对此进行积极研究。在这里，我们广泛阐述了调节性 B 细胞在癌症中的历史，并总结了最近的研究，这些研究为调节性 B 细胞功能的遗传模型奠定了基础，并为实体癌中调节性 B 细胞功能及其治疗干预的潜力提供了依据。
