Kamiryo T, Abiko S, Orita T, Aoki H, Watanabe Y, Hiraoka K
Department of Neurosurgery, Yamaguchi University Hospital, Japan.
Surg Neurol. 1988 Jan;29(1):27-31. doi: 10.1016/0090-3019(88)90119-x.
We present a case of fibrous xanthoma in a 6-year-old boy who showed disturbance of consciousness and signs of increased intracranial pressure. A computed tomographic (CT) scan showed bitemporal enhanced masses and hydrocephalus. The patient was operated on in two stages. The tumors were located intradurally and extracerebrally and were firmly attached to the dura mater at the base of the middle fossa. Glial fibrillary acidic protein stain was negative, and histologic examination suggested a diagnosis of bilateral fibrous xanthoma. Postoperative CT scan showed residual tumors and an enlarged choroid plexus adjacent to it. A CT scan at 12 years of age showed no enhanced tumor, but disclosed bitemporal high-density areas and diffuse brain atrophy; the choroid plexus reverted to normal size. The patient showed mental and physical retardation, perhaps owing to the compression of the hypothalamus during early childhood. This would appear to be the first known case of bilateral intracranial fibrous xanthoma.
我们报告一例6岁男孩的纤维性黄色瘤病例，该男孩出现意识障碍和颅内压升高的体征。计算机断层扫描（CT）显示双侧颞部强化肿块及脑积水。患者分两期进行手术。肿瘤位于硬脑膜内和脑外，在中颅窝底部与硬脑膜紧密相连。胶质纤维酸性蛋白染色为阴性，组织学检查提示诊断为双侧纤维性黄色瘤。术后CT扫描显示残留肿瘤及与之相邻的脉络丛增大。12岁时的CT扫描显示无强化肿瘤，但发现双侧颞部高密度区及弥漫性脑萎缩；脉络丛恢复至正常大小。患者出现智力和身体发育迟缓，可能是由于幼儿期下丘脑受压所致。这似乎是首例已知的双侧颅内纤维性黄色瘤病例。
