Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Mustafa Kemal University, Antakya-Hatay, Turkey.
Department of Genetics, Faculty of Veterinary Medicine, Mustafa Kemal University, Antakya-Hatay, Turkey.
Andrologia. 2021 Mar;53(2):e13930. doi: 10.1111/and.13930. Epub 2020 Dec 24.
One of the prominent health problems caused by Aluminium was the decrease in male fertility rates. In the study, the protective effect of Esculetin (ESC) against the reproductive toxicity induced by Aluminium chloride (AlCl ) was investigated. For this purpose, AlCl was administrated to Wistar Albino rats at a dose of 34 mg/kg and ESC was administrated at a dose of 50 mg/kg for 70 days. It was determined that AlCl treatment reduced sperm motility and concentration, increased dead/live rate and abnormal sperm rate. It decreased serum testosterone level, and co-treatment of ESC significantly regulated these values. In the AlCl -treated group, MDA level increased and GSH level, GPx and CAT activities decreased compared with those of the control group. However, co-treatment of ESC showed an amelioratory effect on the values except for CAT activity. It was observed that the expression level of NRF-2 increased in the ESC and AlCl + ESC groups, and NF-κB increased in the AlCl group with the control group. It was determined that Caspase-3 expression decreased, and Bcl-2 expression increased in AlCl + ESC group compared to AlCl group. It was also determined that AlCl -induced tissue injury was significantly prevented by ESC co-treatment.
铝引起的突出健康问题之一是男性生育力下降。在这项研究中，研究了秦皮素（ESC）对氯化铝（AlCl ）诱导的生殖毒性的保护作用。为此，将 AlCl 以 34mg/kg 的剂量给予 Wistar 白化大鼠，将 ESC 以 50mg/kg 的剂量给予 ESC 70 天。结果表明，AlCl 处理降低了精子活力和浓度，增加了死/活率和异常精子率。它降低了血清睾酮水平，而 ESC 的共同治疗显著调节了这些值。与对照组相比，在 AlCl 处理组中 MDA 水平增加，GSH 水平、GPx 和 CAT 活性降低。然而，除了 CAT 活性外，ESC 的共同治疗对这些值表现出改善作用。观察到 ESC 和 AlCl + ESC 组中的 NRF-2 表达水平增加，而 NF-κB 在 AlCl 组中增加，而对照组中则增加。与 AlCl 组相比，AlCl + ESC 组中的 Caspase-3 表达减少，Bcl-2 表达增加。还确定 ESC 共同治疗显着预防了 AlCl 引起的组织损伤。
