Ju Shaohua, Tan Youli, Wang Qiang, Zhou Ling, Wang Kun, Wen Chenghong, Wang Mingjian
Department of Pharmacy, Affiliated Sport Hospital, Chengdu Sport University, Chengdu, Sichuan 610041, P.R. China.
Exp Ther Med. 2024 Apr 12;27(6):248. doi: 10.3892/etm.2024.12536. eCollection 2024 Jun.
is a deciduous tree, which is distributed worldwide and has important medicinal value. In Asia, the bark of is a commonly used traditional Chinese medicine called Qinpi. Esculetin is a coumarin compound derived from the bark of and its glycoside form is called esculin. The aim of the present study was to systematically review relevant literature on the antioxidant and anti-inflammatory effects of esculetin and esculin. Esculetin and esculin can promote the expression of various endogenous antioxidant proteins, such as superoxide dismutase, glutathione peroxidase and glutathione reductase. This is associated with the activation of the nuclear factor erythroid-derived factor 2-related factor 2 signaling pathway. The anti-inflammatory effects of esculetin and esculin are associated with the inhibition of the nuclear factor κ-B and mitogen-activated protein kinase inflammatory signaling pathways. In various inflammatory models, esculetin and esculin can reduce the expression levels of various proinflammatory factors such as tumor necrosis factor-α, interleukin (IL)-1β and IL-6, thereby inhibiting the development of inflammation. In summary, esculetin and esculin may be promising candidates for the treatment of numerous diseases associated with inflammation and oxidative stress, such as ulcerative colitis, acute lung and kidney injury, lung cancer, acute kidney injury.
它是一种落叶乔木，分布于世界各地，具有重要的药用价值。在亚洲，它的树皮是一种常用的中药，叫做秦皮。七叶亭是一种从其树皮中提取的香豆素化合物，其糖苷形式称为七叶苷。本研究的目的是系统评价有关七叶亭和七叶苷抗氧化和抗炎作用的相关文献。七叶亭和七叶苷可以促进各种内源性抗氧化蛋白的表达，如超氧化物歧化酶、谷胱甘肽过氧化物酶和谷胱甘肽还原酶。这与核因子红细胞衍生因子2相关因子2信号通路的激活有关。七叶亭和七叶苷的抗炎作用与抑制核因子κ-B和丝裂原活化蛋白激酶炎症信号通路有关。在各种炎症模型中，七叶亭和七叶苷可以降低各种促炎因子如肿瘤坏死因子-α、白细胞介素（IL）-1β和IL-6的表达水平，从而抑制炎症的发展。综上所述，七叶亭和七叶苷可能是治疗多种与炎症和氧化应激相关疾病的有前途的候选药物，如溃疡性结肠炎、急性肺和肾损伤、肺癌、急性肾损伤。
