Tran Jennifer M, Kelly Kristen M, Drolet Beth A, Krakowski Andrew C, Arkin Lisa M
Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Department of Dermatology, University of California Irvine, Irvine, CA, USA.
Pediatr Dermatol. 2021 Mar;38(2):351-358. doi: 10.1111/pde.14503. Epub 2020 Dec 27.
Port-wine birthmarks (PWBs) are progressive vascular malformations with significant disfigurement and psychosocial morbidity; early light-based treatment has shown improved outcomes in the pediatric population. Somatic mosaic mutations underly the progressive nature of PWBs and explain the significant differences in response and heterogeneity of vessel architecture in the pediatric population when compared to the adult cohort. Here, we summarize a review of pediatric specific literature on the various light-based treatment modalities, including pulsed dye laser, near-infrared lasers, and intense pulsed light, providing the various indications, tips, advantages, and disadvantages for the pediatric dermatologist.
葡萄酒色斑（PWBs）是一种进行性血管畸形，会导致严重的容貌损毁和心理社会疾病；早期光基治疗已显示在儿科人群中能取得更好的治疗效果。体细胞镶嵌突变是PWBs进行性本质的基础，这也解释了与成人队列相比，儿科人群在血管结构反应和异质性方面存在的显著差异。在此，我们总结了一篇关于儿科特定文献的综述，内容涉及各种光基治疗方式，包括脉冲染料激光、近红外激光和强脉冲光，为儿科皮肤科医生提供了各种适应症、治疗要点、优点和缺点。
