Multiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, Germany.
Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany.
Arch Pharm (Weinheim). 2021 Apr;354(4):e2000378. doi: 10.1002/ardp.202000378. Epub 2020 Dec 23.
Many diseases as well as acute conditions can lead to fatigue, which can be either temporary or chronic in nature. Acute fatigue develops frequently after physical exercise or after alcohol hangover, whereas microbial infections such as influenza or COVID-19 and chronic diseases like Parkinson's disease or multiple sclerosis are often associated with chronic fatigue. Oxidative stress and a resulting disturbance of mitochondrial function are likely to be common denominators for many forms of fatigue, and antioxidant treatments have been shown to be effective in alleviating the symptoms of fatigue. In this study, we review the role of reactive oxygen and nitrogen species in fatigue and the antioxidant effects of the intake of molecular hydrogen. We propose that molecular hydrogen is well suited for the treatment of temporary and chronic forms of oxidative stress-associated fatigue.
许多疾病以及急性病症都可导致疲劳，其性质可为暂时的或慢性的。急性疲劳常发生于体力活动后或宿醉之后，而微生物感染（如流感或 COVID-19）和慢性疾病（如帕金森病或多发性硬化症）常伴有慢性疲劳。氧化应激以及由此导致的线粒体功能紊乱可能是多种形式疲劳的共同因素，抗氧化治疗已被证明可有效缓解疲劳症状。在本研究中，我们综述了活性氧和活性氮在疲劳中的作用，以及摄入氢气的抗氧化作用。我们提出，氢气非常适合治疗与氧化应激相关的急性和慢性疲劳。
