The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Department of Pharmacy, Anhui Provincial Hospital, Anhui Medical University, Hefei, China.
Phytother Res. 2021 Jun;35(6):2945-2967. doi: 10.1002/ptr.7002. Epub 2020 Dec 25.
Atherosclerosis is a chronic inflammatory, metabolic, and epigenetic disease, which leads to the life-threatening coronary artery disease. Emerging studies from bench to bedside have demonstrated the pivotal role of low-density lipoprotein (LDL) oxidation in the initiation and progression of atherosclerosis. This article hereby reviews oxidation mechanism of LDL, and the pro-atherogenic and biomarker role of oxidized LDL in atherosclerosis. We also review the pharmacological effects of several representative natural products (vitamin E, resveratrol, quercetin, probucol, tanshinone IIA, epigallocatechin gallate, and Lycopene) in protecting against LDL oxidation and atherosclerosis. Clinical and basic research supports the beneficial effects of these natural products in inhibiting LDL oxidation and preventing atherosclerosis, but the data are still controversial. This may be related to factors such as the population and the dosage and time of taking natural products involved in different studies. Understanding the mechanism of LDL oxidation and effect of oxidized LDL help researchers to find novel therapies against atherosclerosis.
动脉粥样硬化是一种慢性炎症、代谢和表观遗传疾病，可导致危及生命的冠状动脉疾病。从基础到临床的新兴研究表明，低密度脂蛋白 (LDL) 氧化在动脉粥样硬化的发生和发展中起关键作用。本文综述了 LDL 的氧化机制，以及氧化型 LDL 在动脉粥样硬化中的促动脉粥样硬化和生物标志物作用。我们还综述了几种代表性天然产物（维生素 E、白藜芦醇、槲皮素、普罗布考、丹参酮 IIA、没食子儿茶素没食子酸酯和番茄红素）在预防 LDL 氧化和动脉粥样硬化方面的药理作用。临床和基础研究支持这些天然产物在抑制 LDL 氧化和预防动脉粥样硬化方面的有益作用，但数据仍存在争议。这可能与不同研究中涉及的人群以及天然产物的剂量和服用时间等因素有关。了解 LDL 氧化的机制和氧化型 LDL 的作用有助于研究人员寻找针对动脉粥样硬化的新疗法。
