Department of Genetic Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Chennai, India.
Department of Biotechnology, College of Engineering and Technology, SRM Institute of Science and Technology, Chennai, India.
Phytother Res. 2021 Jun;35(6):2925-2944. doi: 10.1002/ptr.7001. Epub 2020 Dec 25.
Globally, one of the alarming problems is the prevalence and burden of liver diseases, which accounts for 2 million cases per year. Chronic liver aetiologies such as hepatitis infections, alcoholic or non-alcoholic liver disease, environmental agents, and drug-induced toxicity are invariably responsible for liver fibrosis progression to finally hepatocellular carcinoma. Current treatment options are unable to overwhelm and cure liver diseases. Emerging findings suggest researchers' interest in using evidence-based complementary medicine such as ellagic acid with extensive pharmacological properties. They include antioxidant, anti-inflammatory, anti-hyperlipidaemic, anti-viral, anti-angiogenic, and anticancer activity. The molecular functions elicited by ellagic acid include scavenging of free radicals, regulation of lipid metabolism, the prohibition of fibrogenesis response-mediating proteins, inhibits hepatic stellate cells and myofibroblasts, restrains hepatic viral replication, facilitates suppression of growth factors, regulates transcription factors, proinflammatory cytokines, augments the liver immune response, fosters apoptosis and inhibits cell proliferation in tumorigenic cells. This review will most notably focus on preclinical and clinical information based on currently available evidence to warrant ellagic acid's prospective role in preventing liver diseases.
全球范围内，一个令人担忧的问题是肝脏疾病的流行和负担，每年有 200 万例。慢性肝脏病因，如肝炎感染、酒精性或非酒精性肝病、环境因素和药物诱导的毒性，总是导致肝纤维化进展最终导致肝细胞癌。目前的治疗选择无法克服和治愈肝脏疾病。新出现的研究结果表明，研究人员对使用基于证据的补充医学（如具有广泛药理特性的鞣花酸）感兴趣。它们包括抗氧化、抗炎、抗高脂血症、抗病毒、抗血管生成和抗癌活性。鞣花酸引起的分子功能包括清除自由基、调节脂质代谢、禁止纤维化反应介导的蛋白质、抑制肝星状细胞和肌成纤维细胞、抑制肝病毒复制、促进生长因子抑制、调节转录因子、促炎细胞因子、增强肝脏免疫反应、促进细胞凋亡和抑制肿瘤细胞增殖。这篇综述将特别关注基于现有证据的临床前和临床信息，以证明鞣花酸在预防肝脏疾病方面的潜在作用。
