State Key Laboratory of Geohazard Prevention and Geoenvironment Protection, College of Materials, Chemistry & Chemical Engineering, Chengdu University of Technology, 1 Dongsan Road, Erxianqiao, Chengdu, 610059, China.
Chem Rec. 2021 Feb;21(2):396-416. doi: 10.1002/tcr.202000134. Epub 2020 Dec 23.
Sulfoximines are widely used as medicines, agricultural chemicals, chiral precursors, and chiral ligands in asymmetric synthesis, as well as pivotal intermediates for the construction of heterocyclic compounds. NH-sulfoximines may be synthesized from thioethers, sulfoxides, sulfilimines, and sulfinamides. NH-sulfoximines can undergo various transformations, such as arylations, alkylations, vinylations, and alkynylations. Here, we review the methods that have been applied to the syntheses and transformations of NH-sulfoximines.
亚砜亚胺广泛用作药物、农用化学品、手性前体和不对称合成中的手性配体，也是杂环化合物构建的关键中间体。NH-亚砜亚胺可由硫醚、亚砜、亚磺酰胺和亚磺酰亚胺合成。NH-亚砜亚胺可以经历各种转化，如芳基化、烷基化、乙烯基化和炔基化。在这里，我们综述了应用于 NH-亚砜亚胺的合成和转化的方法。
