GKT School of Medical Education, King's College London, London, UK.
Paediatric Liver, GI and Nutrition Centre and Mowatlabs, King's College Hospital, London, UK.
Child Psychiatry Hum Dev. 2021 Dec;52(6):1194-1217. doi: 10.1007/s10578-020-01112-3. Epub 2020 Dec 28.
Childhood exposure to alcohol misuse by household adults has been related to childhood developmental delay, cognitive impacts, mental illness, and problem behaviours. Most evidence comes from high income countries. This systematic review only included studies from low- and middle-income countries (LMICs). Five databases were searched from 1990-2020. Twenty-eight studies of children 0-12 years were included, with 42,599 participants from 11 LMICs. The most common outcome was behavioural problems/disorders (19 studies). Despite varying study designs, this review found that alcohol misuse by household members in LMICs is associated with adverse child neurodevelopmental outcomes, although casual inferences cannot be drawn in the absence of well conducted prospective studies. Statistically significant correlations were described between parental alcohol misuse and child emotional and behavioural difficulties, cognitive delay, and risky behaviours. In future, prospective cohort studies are recommended, with adjustment for confounders.
儿童时期暴露于家庭成人性嗜酒会导致儿童发育迟缓、认知影响、精神疾病和行为问题。大多数证据来自高收入国家。本系统评价仅纳入来自中低收入国家（LMICs）的研究。从 1990 年至 2020 年，在五个数据库中进行了搜索。共纳入 11 个 LMICs 的 28 项针对 0-12 岁儿童的研究，共有 42,599 名参与者。最常见的结果是行为问题/障碍（19 项研究）。尽管研究设计各异，但本综述发现，LMIC 中家庭成员的性嗜酒会导致儿童神经发育不良，尽管由于缺乏精心设计的前瞻性研究，无法得出因果关系。描述了父母性嗜酒与儿童情绪和行为困难、认知延迟和危险行为之间的显著相关性。未来，建议进行前瞻性队列研究，并进行混杂因素调整。
