Christensen C W, Reeves W C, Lassar T A, Schmidt D H
University of Wisconsin Medical School, Milwaukee Clinical Campus, Mount Sinai Medical Center 53233.
Am Heart J. 1988 Jan;115(1 Pt 1):30-7. doi: 10.1016/0002-8703(88)90514-5.
Perfusion of the coronary artery distal to an occlusion was performed in 16 canine preparations to compare the mechanical perfusion of autologous blood to the perfluorocarbon fluosol DA, 20% emulsion (FDA-20). Both substances were perfused under similar conditions (30, 60, and 80 ml/min) and regional electrograms, contractility, and coronary perfusion were measured relative to native coronary perfusion. Autologous blood (60 and 80 ml/min) produced a significant increase in regional (epicardial, midmyocardial, and endocardial) and transmural flow, but not in the endocardial/epicardial perfusion ratio. No other significant changes were observed during autologous blood perfusion. In contrast, FDA-20 perfusion resulted in significant ST depression (-1.8 +/- 0.2, -1.7 +/- 0.2, and -1.3 +/- 0.3 mm) at 30, 60, and 80 ml/min, respectively. FDA-20 also induced a significant decrease in distal diastolic coronary pressure and resistance, a significant decrease in the endocardial/epicardial perfusion ratio at all three perfusion rates, and a significant reduction in delivery of O2 to the subendocardium. These results indicate that autologous blood perfusion of the distal coronary artery during occlusion preserves myocardial function to a better degree than does FDA-20.
在16只犬的实验准备中，对闭塞远端的冠状动脉进行灌注，以比较自体血与全氟碳化合物氟索DA 20%乳剂（FDA - 20）的机械灌注情况。两种物质均在相似条件下（30、60和80毫升/分钟）进行灌注，并相对于天然冠状动脉灌注测量局部心电图、收缩性和冠状动脉灌注。自体血（60和80毫升/分钟）使局部（心外膜、心肌中层和心内膜）和透壁血流显著增加，但心内膜/心外膜灌注比未增加。在自体血灌注期间未观察到其他显著变化。相比之下，FDA - 20灌注在30、60和80毫升/分钟时分别导致显著的ST段压低（-1.8±0.2、-1.7±0.2和-1.3±0.3毫米）。FDA - 20还导致远端舒张期冠状动脉压力和阻力显著降低，在所有三种灌注速率下心内膜/心外膜灌注比显著降低，以及心内膜下O2输送显著减少。这些结果表明，闭塞期间远端冠状动脉的自体血灌注比FDA - 20能更好地保护心肌功能。
