Department of Pediatrics, University of Cincinnati College of Medicine.
Cancer and Blood Diseases Institute.
J Pediatr Hematol Oncol. 2022 Jan 1;44(1):e237-e240. doi: 10.1097/MPH.0000000000002036.
Influenza virus can trigger atypical hemolytic uremic syndrome and present with complement-driven thrombotic microangiopathy (TMA). When administered promptly, complement-blocking therapies can spare organ injury and be lifesaving. However, diagnosing TMA in the setting of a severe viral infection can be challenging, as a significant overlap of symptoms and disease complications exists. This is particularly true in influenza virus infections and more recently, Coronavirus disease 2019 (COVID-19) infections. We present a 16-year-old male with H1N1 influenza-induced atypical hemolytic uremic syndrome who quickly improved with complement-blocking therapy, highlighting an urgent need to include TMA in the differential diagnosis of severe viral infections.
流感病毒可引发非典型溶血性尿毒症综合征，并表现为补体驱动的血栓性微血管病（TMA）。及时给予补体抑制剂治疗，可以避免器官损伤，甚至挽救生命。然而，在严重病毒感染的情况下，TMA 的诊断具有挑战性，因为症状和疾病并发症存在显著重叠。在流感病毒感染和最近的 2019 冠状病毒病（COVID-19）感染中尤其如此。我们报告了一例 16 岁男性，因 H1N1 流感引起非典型溶血性尿毒症综合征，经补体抑制剂治疗后迅速改善，这突出表明需要将 TMA 纳入严重病毒感染的鉴别诊断。
