From the Department of Medicine, Mayo Clinic Cancer Center, Phoenix, AZ.
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH.
Pancreas. 2021 Jan 1;50(1):47-53. doi: 10.1097/MPA.0000000000001723.
In this study, we aimed to determine the cause of death (COD) after the diagnosis of neuroendocrine tumors (NET).
We used the Surveillance, Epidemiology and End Results (SEER) Program to review patients diagnosed with NET during 2000 to 2016. Patients were followed until death, and different CODs were determined.
Of 94,399 patients with NETs, 40.9% died during the study period. During the first year of diagnosis, most deaths were from NETs (73%), followed by other cancers (11.2%) and cardiac diseases (4.6%). After more than 10 years, NET deaths decreased to 24.3%, whereas other cancers and cardiac disease became more common. Neuroendocrine tumors were responsible for 42.8%, 63.4%, and 81.2% of deaths in grade I, grade II, and grade III, respectively. For grade I localized NET, other cancers (22.2%) were the most common COD followed by NET (19.7%), whereas in grade 2 localized NET, NET was COD in 31.1% of cases followed by other cancers (22.4%). In metastatic disease, NET was the most common COD regardless of grade.
For low-grade localized NET, deaths were mostly secondary to non-NET causes. In contrast, NET is responsible for most of deaths in metastatic NET regardless of grade.
本研究旨在确定神经内分泌肿瘤（NET）诊断后的死亡原因（COD）。
我们使用监测、流行病学和最终结果（SEER）计划回顾了 2000 年至 2016 年间诊断为 NET 的患者。患者随访至死亡，并确定了不同的 COD。
在 94399 例 NET 患者中，40.9%在研究期间死亡。在诊断后的第一年，大多数死亡是由 NET 引起的（73%），其次是其他癌症（11.2%）和心脏疾病（4.6%）。10 年以上后，NET 死亡人数下降至 24.3%，而其他癌症和心脏疾病则更为常见。NET 分别占 I 级、II 级和 III 级肿瘤死亡的 42.8%、63.4%和 81.2%。对于 I 级局限性 NET，其他癌症（22.2%）是最常见的 COD，其次是 NET（19.7%），而对于 2 级局限性 NET，NET 是 COD 的占 31.1%，其次是其他癌症（22.4%）。在转移性疾病中，NET 是最常见的 COD，无论分级如何。
对于低级别局限性 NET，死亡主要继发于非 NET 原因。相比之下，NET 是转移性 NET 中大多数死亡的主要原因，无论分级如何。
