酒精对冠心病患者静息及直立运动时血流动力学的影响。

Hemodynamic effects of alcohol at rest and during upright exercise in coronary artery disease.

作者信息

Kelbaek H, Heslet L, Skagen K, Christensen N J, Godtfredsen J, Munck O

机构信息

Department of Clinical Physiology and Nuclear Medicine, Herlev Hospital, University of Copenhagen, Denmark.

出版信息

Am J Cardiol. 1988 Jan 1;61(1):61-4. doi: 10.1016/0002-9149(88)91305-7.

DOI:10.1016/0002-9149(88)91305-7

PMID:3337017

Abstract

The hemodynamic effects of acute alcohol intoxication were studied at rest and during upright exercise in 28 patients with coronary artery disease by right-sided heart catheterization and radionuclide cardiography. The mean arterial blood pressure at rest was reduced by 5% and the left ventricular ejection fraction at rest decreased 2% because of end-systolic dilation during intoxication (serum ethanol 21 mmol/liter). No changes were observed in heart rate, stroke volume, pulmonary artery pressure, pulmonary artery wedge pressure or total peripheral resistance. No significant changes occurred in plasma catecholamines, and no changes occurred in any variable during mild exercise corresponding to a 30 to 40% heart rate increase. Thus, alcohol ingested in moderate doses causes slight impairment of left ventricular emptying and a reduction in the arterial blood pressure at rest in patients with coronary artery disease. A mild exercise load can be tolerated during alcohol intoxication without hemodynamic changes.

摘要

通过右侧心导管插入术和放射性核素心动图，对28例冠状动脉疾病患者在静息状态和直立运动期间急性酒精中毒的血流动力学效应进行了研究。静息时平均动脉血压降低了5%，静息时左心室射血分数降低了2%，这是由于中毒期间（血清乙醇21 mmol/升）的收缩末期扩张所致。心率、每搏输出量、肺动脉压、肺动脉楔压或总外周阻力均未观察到变化。血浆儿茶酚胺无显著变化，在对应心率增加30%至40%的轻度运动期间，任何变量均无变化。因此，中等剂量摄入酒精会导致冠状动脉疾病患者左心室排空略有受损，静息时动脉血压降低。酒精中毒期间可以耐受轻度运动负荷，而不会发生血流动力学变化。