Krzyzaniak R L, Buss D H, Cooper M R, Wells H B
Department of Pathology, Wake Forest University, Bowman Gray School of Medicine, Winston-Salem, North Carolina 27103.
Am J Clin Pathol. 1988 Jan;89(1):63-8. doi: 10.1093/ajcp/89.1.63.
A retrospective review of pretreatment bone marrow material from 297 patients diagnosed and treated for multiple myeloma (MM) at a single institution during a 22-year period (1961-1982) was performed in order to assess the frequency and significance of associated simple marrow fibrosis (SMF). The presence of SMF was suspected in the hematoxylin and eosin-stained sections in 48 of the 297 cases and was confirmed by reticulin stains in 26 (8.8%) cases, with seven of these also showing collagen on trichrome stain. However, the literature on MM documents little recognition of this association. SMF is often responsible for inadequate marrow aspirates yielding spurious or inconclusive results. Thus, bone marrow trephine biopsies may be required to histologically confirm the diagnosis of MM when there is concurrent SMF.
为评估相关单纯性骨髓纤维化（SMF）的发生率及意义，我们对某机构在1961年至1982年这22年间确诊并接受治疗的297例多发性骨髓瘤（MM）患者的预处理骨髓材料进行了回顾性研究。在297例病例中，苏木精-伊红染色切片中有48例怀疑存在SMF，经网状纤维染色证实26例（8.8%）存在SMF，其中7例经三色染色也显示有胶原纤维。然而，关于MM的文献中很少提及这种关联。SMF常导致骨髓穿刺抽吸不足，从而产生假阳性或不确定的结果。因此，当同时存在SMF时，可能需要进行骨髓环钻活检以从组织学上确诊MM。
