Murayama T, Matsui T, Hayashi Y, Taniguchi T, Ito M, Natazuka T, Imoto S, Iwata N, Isobe T, Ito H
Department of Medicine, Kobe University School of Medicine, Japan.
Ann Hematol. 1994 Sep;69(3):151-2. doi: 10.1007/BF01695697.
We describe a case of plasma cell leukemia associated with myelofibrosis. A 60-year-old woman was admitted due to lumbago and monoclonal hypergammaglobulinemia. Peripheral blood showed about 40% of plasma-cell-like cells. A bone marrow aspiration was dry tap. The patient was diagnosed as having plasma cell leukemia with myelofibrosis by bone marrow biopsy. Plasma cell leukemia as well as myelofibrosis improved with combination chemotherapy using vincristine, pirarubicin, and dexamethasone. However, when plasma cell leukemia became resistant to chemotherapies, myelofibrosis also reappeared. This case strongly suggests the pathogenetic relationship between plasma cell leukemia and myelofibrosis.
我们描述了一例与骨髓纤维化相关的浆细胞白血病病例。一名60岁女性因腰痛和单克隆高球蛋白血症入院。外周血显示约40%的浆细胞样细胞。骨髓穿刺为干抽。通过骨髓活检，该患者被诊断为患有伴骨髓纤维化的浆细胞白血病。使用长春新碱、吡柔比星和地塞米松的联合化疗使浆细胞白血病以及骨髓纤维化得到改善。然而，当浆细胞白血病对化疗产生耐药性时，骨髓纤维化也再次出现。该病例有力地提示了浆细胞白血病与骨髓纤维化之间的发病机制关系。
