Pathology, Aga Khan University Hospital, Karachi, Pakistan.
Surgery (Urology Section), Aga Khan University Hospital, Karachi, Pakistan
BMJ Case Rep. 2020 Dec 22;13(12):e236280. doi: 10.1136/bcr-2020-236280.
Malignant lymphomas of the prostate are very rare tumours and are generally not considered in the clinical or pathological diagnosis of prostatic enlargement. We report a case of a 56-year-old man who presented with long-standing history of low back pain and a 2-month history of voiding lower urinary tract symptoms. He denied any history of urinary retention, trauma, catheterisation or any constitutional symptoms. Examination revealed no lymphadenopathy and hepatosplenomegaly. Digital rectal examination showed an irregular, moderately enlarged nodular prostate. His prostate-specific antigen was 1.54 ng/mL. MRI of the pelvis did not show any focal lesion apart from abnormal signal intensity in the central zone. Bone scan was negative. Transrectal ultrasound-guided prostate biopsy revealed diffuse large B cell lymphoma. Bone marrow biopsy and whole body positron emission tomography/CT were unremarkable. The patient achieved complete remission after receiving six cycles of R-CHOP chemotherapy.
前列腺恶性淋巴瘤非常罕见，在前列腺增大的临床或病理诊断中通常不考虑。我们报告了一例 56 岁男性，他长期有腰痛病史，并有 2 个月的下尿路排尿症状。他否认有尿潴留、创伤、导尿或任何全身症状史。检查未发现淋巴结病和肝脾肿大。直肠指检显示前列腺不规则，中等大小，有结节。他的前列腺特异性抗原为 1.54ng/ml。骨盆 MRI 除中央区信号异常外，未见局灶性病变。骨扫描阴性。经直肠超声引导前列腺活检显示弥漫性大 B 细胞淋巴瘤。骨髓活检和全身正电子发射断层扫描/CT 未见异常。患者接受 6 个周期 R-CHOP 化疗后达到完全缓解。
