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自然杀伤细胞和自然杀伤 T 细胞对牙周病的影响：对当前文献的系统评价。

Influence of Natural Killer Cells and Natural Killer T Cells on Periodontal Disease: A Systematic Review of the Current Literature.

机构信息

Dental Practice, Bahnhofstraße 10, 82223 Eichenau, Germany.

Department of Orthodontics and Orofacial Orthopedics, Universitätsklinikum Erlangen and Friedrich-Alexander Universität (FAU) Erlangen-Nürnberg, Glückstr. 11, 91054 Erlangen, Germany.

出版信息

Int J Mol Sci. 2020 Dec 21;21(24):9766. doi: 10.3390/ijms21249766.

DOI:10.3390/ijms21249766
PMID:33371393
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7767411/
Abstract

Natural killer (NK) cells, as members of the innate immune system, and natural killer T (NKT) cells, bridging innate and adaptive immunity, play a prominent role in chronic inflammatory diseases and cancerogenesis, yet have scarcely been examined in oral diseases. Therefore, systematic research on the latest literature focusing on NK/NKT cell-mediated mechanisms in periodontal disease, including the time period 1988-2020, was carried out in MEDLINE (PubMed) using a predetermined search strategy, with a final selection of 25 studies. The results showed that NK cells tend to have rather proinflammatory influences via cytokine production, cytotoxic effects, dendritic-cell-crosstalk, and autoimmune reactions, while contrarily, NKT cell-mediated mechanisms were proinflammatory and immunoregulatory, ranging from protective effects via B-cell-regulation, specific antibody production, and the suppression of autoimmunity to destructive effects via cytokine production, dendritic-cell-crosstalk, and T-/B-cell interactions. Since NK cells seem to have a proinflammatory role in periodontitis, further research should focus on the proinflammatory and immunoregulatory properties of NKT cells in order to create, in addition to antibacterial strategies in dental inflammatory disease, novel anti-inflammatory therapeutic approaches modulating host immunity towards dental health.

摘要

自然杀伤 (NK) 细胞作为先天免疫系统的成员，以及自然杀伤 T (NKT) 细胞作为连接先天和适应性免疫的桥梁，在慢性炎症性疾病和癌症发生中发挥着重要作用，但在口腔疾病中几乎没有得到研究。因此，对 1988 年至 2020 年期间牙周病中 NK/NKT 细胞介导机制的最新文献进行了系统研究，在 MEDLINE（PubMed）中使用预定的搜索策略进行了研究，最终选择了 25 项研究。结果表明，NK 细胞通过细胞因子产生、细胞毒性作用、树突状细胞相互作用和自身免疫反应表现出较强的促炎作用，而相反，NKT 细胞介导的机制具有促炎和免疫调节作用，从通过 B 细胞调节、特异性抗体产生和抑制自身免疫的保护作用，到通过细胞因子产生、树突状细胞相互作用和 T/B 细胞相互作用的破坏作用。由于 NK 细胞在牙周炎中似乎具有促炎作用，因此应进一步研究 NKT 细胞的促炎和免疫调节特性，以便除了在牙科炎症性疾病中采用抗菌策略外，还能创造出调节宿主免疫以促进牙齿健康的新型抗炎治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6678/7767411/5c5561e3b14e/ijms-21-09766-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6678/7767411/8ec30438af29/ijms-21-09766-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6678/7767411/8ec30438af29/ijms-21-09766-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6678/7767411/937edb23803b/ijms-21-09766-g002.jpg
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2
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3
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