Mathews Marc J, Mathews Edward H, Mathews George E
CRCED, North-West University, P.O. Box 11207, Silver Lakes, 0054, South Africa.
BMC Oral Health. 2016 Nov 15;16(1):122. doi: 10.1186/s12903-016-0316-7.
It is well documented that there is some correlation between poor oral health in the form of periodontal disease and coronary heart disease (CHD). It is unclear whether this correlation is due to a causal relationship or shared underlying disorder such as inflammation. A suitable integrated model of the CHD pathogenetic pathways relevant to periodontal disease may help to elucidate the association. Such a model is currently not available in literature.
A previously developed integrated model of CHD was used to investigate potential pathogenetic pathways linking periodontal disease to CHD biomarkers.
The integrated model was created to provide insight into possible higher-order biological interactions underlying CHD and periodontal disease. In order to simplify these interactions a novel 'connection graph' was developed. It quantitatively illustrates the relationship between periodontal disease and various serological biomarkers of CHD. The pathogenesis of periodontitis shows various possible pathways which could link periodontitis to CHD pathogenesis.
An integrated model of CHD was developed which provides a summary of the potential CHD effects of periodontal disease. Further research must refine and validate the model.
有充分文献记载，牙周病形式的口腔健康不良与冠心病（CHD）之间存在一定关联。目前尚不清楚这种关联是由于因果关系还是诸如炎症等共同的潜在紊乱所致。一个与牙周病相关的冠心病发病机制的合适综合模型可能有助于阐明这种关联。目前文献中尚无此类模型。
使用先前开发的冠心病综合模型来研究将牙周病与冠心病生物标志物联系起来的潜在发病机制途径。
创建综合模型是为了深入了解冠心病和牙周病潜在的高阶生物相互作用。为了简化这些相互作用，开发了一种新颖的“连接图”。它定量地说明了牙周病与冠心病各种血清生物标志物之间的关系。牙周炎的发病机制显示出多种可能将牙周炎与冠心病发病机制联系起来的途径。
开发了一个冠心病综合模型，该模型总结了牙周病对冠心病的潜在影响。进一步的研究必须完善并验证该模型。
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