School of Mathematics and Information Science, Guiyang University, Guiyang 550005, China.
Chaotic Matter Science Research Center, Jiangxi University of Science and Technology Nanchang Campus, Nanchang 330013, China.
Curr Org Synth. 2021;18(4):377-387. doi: 10.2174/1570179417999201228214930.
The phosphorus-containing heterocycles are an important class of compounds in organic chemistry. Because of their potential application in many fields, especially, the synthetic pesticides, medicine and catalyst, the phosphorus-containing heterocycles have attracted continuous attention from organic synthesis scientists. The development of efficient and low-cost catalytic systems is of great interest for the construction of heterocycles C-P bond. Usually, the phosphorus-containing heterocycles is prepared via direct carbon-hydrogen (C-H) bond activation or pre-functionalized of heterocycles with phosphorus-hydrogen (P-H) bond of phosphorus compounds reaction by metal-catalyzed. This review summarizes recent progress in the heterocycles C-P bond formation reactions by metal-catalyzed, which mainly focus on the discussion of the reaction mechanism. It aims to provide efficient methods for the future synthesis and application in this field.
含磷杂环化合物是有机化学中一类重要的化合物。由于它们在许多领域的潜在应用，特别是在合成农药、医药和催化剂方面，含磷杂环化合物一直吸引着有机合成科学家的持续关注。高效、低成本催化体系的发展对于构建杂环 C-P 键具有重要意义。通常，含磷杂环化合物是通过直接碳-氢键（C-H）活化或杂环与磷化合物的磷-氢键（P-H）反应的预官能化来制备的，这是通过金属催化来实现的。本综述总结了近年来金属催化的杂环 C-P 键形成反应的最新进展，主要集中在反应机理的讨论上。旨在为该领域的未来合成和应用提供有效的方法。
