Gunasegaran Preetha, Tahmina Sultana, Daniel Mary, Nanda Sunil K
Department of Obstetrics and Gynaecology, Pondicherry Institute of Medical Sciences, Puducherry, India.
Department of Obstetrics and Gynaecology, Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research, Melmaruvathur, Tamil Nadu, India.
J Obstet Gynaecol Res. 2021 Mar;47(3):1016-1022. doi: 10.1111/jog.14629. Epub 2020 Dec 28.
To assess role of vitamin D-calcium supplementation on the metabolic profile and oxidative stress in women with Gestational Diabetes Mellitus (GDM) controlled on diet.
A randomized controlled trial was conducted at a tertiary care teaching hospital. Seventy women diagnosed as GDM at 24-28 weeks of gestation, controlled on a diabetic diet, were randomized to receive either vitamin D 1000 IU and calcium 1000 mg (group A, n = 34) or vitamin D 250 IU and calcium 500 mg (group B, n = 36) daily for 6 weeks. Levels of serum 25-hydroxy vitamin D, fasting plasma glucose (FPG), serum insulin, fasting lipid profile and total glutathione (GSH) were analyzed both prior to and after supplementation. Means, standard deviations and mean change were computed. Paired and independent t-tests were used to determine statistical significance between the two groups.
Women in group A showed a significant reduction in FPG level (P-value = 0.007), fasting serum insulin level (P-value = 0.000), LDL (P-value = 0.000), total cholesterol levels (P-value = 0.000) and increase in HDL levels (P-value = 0.000). Group B had a significant fall only in FPG after 6 weeks supplementation. A significant change in total glutathione level (P-value = 0.000) was observed in both groups.
Vitamin D and calcium supplementation at a dose of 1000 IU and 1000 mg, respectively, has a beneficial role in glucose metabolism, lipid metabolism and oxidative stress in GDM.
评估补充维生素D和钙对饮食控制的妊娠期糖尿病（GDM）女性代谢谱和氧化应激的作用。
在一家三级护理教学医院进行了一项随机对照试验。70名在妊娠24 - 28周被诊断为GDM且通过糖尿病饮食控制的女性，被随机分为两组，分别每日接受1000国际单位维生素D和1000毫克钙（A组，n = 34）或250国际单位维生素D和500毫克钙（B组，n = 36），为期6周。在补充前后分析血清25 - 羟基维生素D、空腹血糖（FPG）、血清胰岛素、空腹血脂谱和总谷胱甘肽（GSH）水平。计算均值、标准差和平均变化。使用配对t检验和独立t检验来确定两组之间的统计学显著性。
A组女性的FPG水平（P值 = 0.007）、空腹血清胰岛素水平（P值 = 0.000）、低密度脂蛋白（P值 = 0.000）、总胆固醇水平（P值 = 0.000）显著降低，高密度脂蛋白水平升高（P值 = 0.000）。B组仅在补充6周后FPG有显著下降。两组的总谷胱甘肽水平均有显著变化（P值 = 0.000）。
分别给予1000国际单位维生素D和1000毫克钙的补充剂，对GDM患者的糖代谢、脂代谢和氧化应激具有有益作用。
