Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Nord J Psychiatry. 2021 Jul;75(5):336-343. doi: 10.1080/08039488.2020.1857832. Epub 2020 Dec 29.
To evaluate the patients' perceptions of clozapine and that of their family caregivers about the positive and negative effects of clozapine.
52 patients and their family caregivers were assessed for their perception of the positive and negative effects of clozapine by using a self-designed questionnaire.
About half (53.8%) of the patients were not distressed of frequent blood testing. At least two-thirds of the patients acknowledged a reduction in psychopathology, achieving clinical stability, improvement in the behavior of others towards them, improvement in their behavior towards others, improvement in regularity in medication intake, agreed that their clinical state will worsen if clozapine is stopped, and reported overall satisfaction/happiness with the intake of clozapine. In general, caregivers also reported similar perceptions. In terms of caregiver outcomes, about two-third to three-fourth of the caregivers reported a reduction in caregiving needs, personal caregiver distress and tension, caregiver burden and time spent in caregiving. About half of the caregivers reported a reduction in the cost of treatment, since the starting of clozapine.
To conclude, the present study suggests that a significant proportion of patients receiving clozapine for three months and their relatives report positive perception and experience with the molecule.
评估氯氮平患者及其家属对氯氮平积极和消极影响的看法。
使用自我设计的问卷评估 52 名患者及其家属对氯氮平积极和消极影响的看法。
约一半（53.8%）的患者不担心频繁的血液检测。至少三分之二的患者承认精神病理学减轻，达到临床稳定，他人对他们的行为改善，他们对他人的行为改善，药物摄入的规律性提高，同意如果停止氯氮平，他们的临床状况会恶化，并报告总体上对氯氮平摄入的满意/幸福感。一般来说，护理人员也报告了类似的看法。在护理人员的结果方面，大约三分之二到四分之三的护理人员报告说，他们的护理需求、个人护理人员的痛苦和紧张、护理人员的负担和护理时间减少了。大约一半的护理人员报告说，自从开始使用氯氮平以来，治疗费用有所减少。
总之，本研究表明，接受氯氮平治疗三个月的患者及其亲属中有相当一部分对该药物有积极的看法和体验。
