Kendler K S, Gruenberg A M, Tsuang M T
Department of Psychiatry, Medical College of Virginia/Virginia Commonwealth University, Richmond 23298.
Am J Psychiatry. 1988 Jan;145(1):57-62. doi: 10.1176/ajp.145.1.57.
The authors conducted a blind family study based on probands diagnosed as schizophrenic by DSM-III and subtyped by four diagnostic systems. The pattern of psychopathology in relatives did not differ as a function of the probands' subtype diagnosis. Relatives of paranoid and nonparanoid schizophrenic probands had similar risks for schizophrenia and affective illness. Resemblance in subtype diagnosis between probands and their affected relatives did not exceed chance expectation. The etiologic role of familial factors appears to be similar in each of the traditional subtypes of schizophrenia. No evidence was found for familial factors specific for individual subtypes.
作者基于被《精神疾病诊断与统计手册》第三版诊断为精神分裂症并通过四种诊断系统进行亚型分类的先证者开展了一项盲法家族研究。亲属的精神病理学模式并不因先证者的亚型诊断而有所不同。偏执型和非偏执型精神分裂症先证者的亲属患精神分裂症和情感性疾病的风险相似。先证者与其患病亲属在亚型诊断上的相似性未超过偶然预期。在精神分裂症的每一种传统亚型中，家族因素的病因学作用似乎都是相似的。未发现针对个别亚型的家族因素证据。
